Protein profile

PA1095

B-type flagellar protein FliS

Genome: NC_002516.2

Gene: PA1095 fliS Structure source: AlphaFold UniProt Q9I4N6
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Amino acids 126
Annotations 3
Features 14
PDB binders 0
Druggability 0.891

Overview

Basic information about this protein and its source genome.

Accession
PA1095
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1095 fliS
Status
annotated
Amino acids
126
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.891
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 126 FunFam G3DSA:1.20.120.340:FF:000001 Flagellar secretion chaperone FliS
1 122 NCBIfam TIGR00208 flagellar export chaperone FliS
1 122 InterPro IPR003713 Flagellar protein FliS
1 126 Gene3D G3DSA:1.20.120.340 Flagellar protein FliS
8 124 Pfam PF02561 Flagellar protein FliS
8 124 InterPro IPR003713 Flagellar protein FliS
1 125 PANTHER PTHR34773 FLAGELLAR SECRETION CHAPERONE FLIS
1 125 InterPro IPR003713 Flagellar protein FliS
1 126 PIRSF PIRSF039090 Flis
1 126 InterPro IPR003713 Flagellar protein FliS
24 125 CDD cd16098 FliS
24 125 InterPro IPR003713 Flagellar protein FliS
8 124 SUPERFAMILY SSF101116 Flagellar export chaperone FliS
8 124 InterPro IPR036584 Flagellar protein FliS superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1095
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.891
2 0.242