Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1100
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: fliE PA1100
Status: annotated
Amino acids: 109
Structure source: AlphaFold

GO

GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). GO:0005198 The action of a molecule that contributes to the structural integrity of a complex. GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor.
GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
GO:0005198 The action of a molecule that contributes to the structural integrity of a complex.
GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
73	89	PRINTS	PR01006	Flagellar hook-basal body complex protein FliE signature
73	89	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE
94	107	PRINTS	PR01006	Flagellar hook-basal body complex protein FliE signature
94	107	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE
38	54	PRINTS	PR01006	Flagellar hook-basal body complex protein FliE signature
38	54	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE
24	109	Pfam	PF02049	Flagellar hook-basal body complex protein FliE
24	109	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE
7	109	PANTHER	PTHR34653	-
7	109	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE
3	109	Hamap	MF_00724	Flagellar hook-basal body complex protein FliE [fliE].
3	109	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE
19	108	NCBIfam	TIGR00205	flagellar hook-basal body complex protein FliE
19	108	InterPro	IPR001624	Flagellar hook-basal body complex protein FliE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA1100 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1100	AlphaFold	—	—	full sequence	—	Viewing