Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1101
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1101 fliF
Status: annotated
Amino acids: 598
Structure source: AlphaFold

GO

GO:0009431 One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.926

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0009431 One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records

Show feature table

Start	End	DB	Term	Name
140	158	PRINTS	PR01009	Flagellar M-ring protein signature
140	158	InterPro	IPR000067	Flagellar M-ring protein FliF
172	186	PRINTS	PR01009	Flagellar M-ring protein signature
172	186	InterPro	IPR000067	Flagellar M-ring protein FliF
215	233	PRINTS	PR01009	Flagellar M-ring protein signature
215	233	InterPro	IPR000067	Flagellar M-ring protein FliF
285	303	PRINTS	PR01009	Flagellar M-ring protein signature
285	303	InterPro	IPR000067	Flagellar M-ring protein FliF
392	416	PRINTS	PR01009	Flagellar M-ring protein signature
392	416	InterPro	IPR000067	Flagellar M-ring protein FliF
139	242	Gene3D	G3DSA:3.30.300.30	-
139	242	InterPro	IPR045851	AMP-binding enzyme, C-terminal domain superfamily
42	61	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
296	392	MobiDBLite	mobidb-lite	consensus disorder prediction
487	509	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	41	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
272	469	Pfam	PF08345	Flagellar M-ring protein C-terminal
272	469	InterPro	IPR013556	Flagellar M-ring C-terminal
514	598	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
42	61	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
28	597	PANTHER	PTHR30046	FLAGELLAR M-RING PROTEIN
28	597	InterPro	IPR043427	Lipoprotein YscJ/Flagellar M-ring protein
63	239	Pfam	PF01514	Secretory protein of YscJ/FliF family
63	239	InterPro	IPR006182	Flagellar M-ring , N-terminal
27	598	PIRSF	PIRSF004862	FliF
27	598	InterPro	IPR000067	Flagellar M-ring protein FliF
34	513	NCBIfam	TIGR00206	flagellar basal-body MS-ring/collar protein FliF
34	513	InterPro	IPR000067	Flagellar M-ring protein FliF
495	513	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
62	494	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1101	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.926
2				0.801
1				0.521

PA1101