Protein target profile

PA1102

flagellar motor switch protein FliG

Genome: NC_002516.2

Gene: PA1102 fliG 3D evidence: AlphaFold DB model UniProt Q51464
Export view
Length 338
Pocket druggability 0.707
EC / GO 0 / 6
Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

4 signals

Strengths

No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Strong predicted binding pocket FPocket selected-pocket score 0.71. This is a computational pocket signal, not binding validation. Structure available AlphaFold DB model

Risks / watch

No major risk signal surfaced in the loaded evidence.

Missing evidence

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.
How to read this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal TPW pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Overview

Basic information about this protein and its source genome.

Accession
PA1102
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1102 fliG
Status
annotated
Amino acids
338
3D evidence
AlphaFold DB model
GO
GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected pocket evidence

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.707
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSENRLAAKLTKVDKAAILLLSLGETDAAQVLRHMGPKEVQRVGVAMASMRNVHREQVEQVMGEFVEVVGDQTSLGVGADGYIRKMLTQALGEDKANNLIDRILLGGSTSGLDSLKWMEPRAVADVIRYEHPQIQAIVVAYLDPDQAAEVLSHFDHKVRLDIVLRVSSLNTVQPSALKELNLILEKQFAGNSNATRTTMGGVKRAADIMNYLDSSIEGQLMDSIREVDEDLSGQIEDLMFVFDNLADVDDRGIQALLREVSSDVLVLALKGSDEAIREKVFKNMSKRAAELLRDDLEAKGPVRVSEVEGAQKEILTIARRMAESGDIVLGGKGGEEMI

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
200 225 PRINTS PR00954 Flagellar motor switch protein FliG signature
200 225 InterPro IPR000090 Flagellar motor switch protein FliG
39 65 PRINTS PR00954 Flagellar motor switch protein FliG signature
39 65 InterPro IPR000090 Flagellar motor switch protein FliG
231 251 PRINTS PR00954 Flagellar motor switch protein FliG signature
231 251 InterPro IPR000090 Flagellar motor switch protein FliG
253 273 PRINTS PR00954 Flagellar motor switch protein FliG signature
253 273 InterPro IPR000090 Flagellar motor switch protein FliG
10 26 PRINTS PR00954 Flagellar motor switch protein FliG signature
10 26 InterPro IPR000090 Flagellar motor switch protein FliG
277 303 PRINTS PR00954 Flagellar motor switch protein FliG signature
277 303 InterPro IPR000090 Flagellar motor switch protein FliG
119 142 PRINTS PR00954 Flagellar motor switch protein FliG signature
119 142 InterPro IPR000090 Flagellar motor switch protein FliG
93 194 Gene3D G3DSA:1.10.220.30 -
12 122 SUPERFAMILY SSF48029 FliG
12 122 InterPro IPR011002 Flagellar motor switch protein FliG, alpha-helical
119 330 SUPERFAMILY SSF48029 FliG
119 330 InterPro IPR011002 Flagellar motor switch protein FliG, alpha-helical
24 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
200 338 Gene3D G3DSA:1.10.220.30 -
3 337 PANTHER PTHR30534 FLAGELLAR MOTOR SWITCH PROTEIN FLIG
3 337 InterPro IPR000090 Flagellar motor switch protein FliG
16 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
5 338 PIRSF PIRSF003161 FliG
5 338 InterPro IPR000090 Flagellar motor switch protein FliG
1 15 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
223 329 Pfam PF01706 FliG C-terminal domain
223 329 InterPro IPR023087 Flagellar motor switch protein FliG, C-terminal
120 193 Pfam PF14841 FliG middle domain
120 193 InterPro IPR032779 Flagellar motor switch protein FliG, middle domain
7 336 NCBIfam TIGR00207 flagellar motor switch protein FliG
7 336 InterPro IPR000090 Flagellar motor switch protein FliG
6 90 FunFam G3DSA:1.10.220.30:FF:000007 Flagellar motor switch protein FliG
29 338 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
4 90 Gene3D G3DSA:1.10.220.30 -
200 338 FunFam G3DSA:1.10.220.30:FF:000001 Flagellar motor switch protein FliG
94 196 FunFam G3DSA:1.10.220.30:FF:000004 Flagellar motor switch protein FliG
9 108 Pfam PF14842 FliG N-terminal domain
9 108 InterPro IPR028263 Flagellar motor switch protein FliG, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold DB PA1102
AlphaFold DB — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sector atoms Pocket Sector Druggability Labels Zoom Positions
1 0.418
6 0.306
2 0.202