Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1110
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1110
Status: annotated
Amino acids: 236
Structure source: AlphaFold

EC

5.4.99.21

GO

GO:0160138 Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0001522 The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0006396 Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0009982 Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0009451 The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.67

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MTDPIRLSKRLAELTACSRREAELYIEGGWVSVDGEVIEEPQFKVLDQRVELLPGARAETIEPATLLLHKPAGWRHDDFEGLLAAGRRWSDDPSPLRALKKHFARQRPTLALDSEASGLVVFSQQHGVLRKLVDDGARLEQEYLVEVAGDLAAGGLERLRHGLAYQGRRLSPCKVSWQNESHLRFALKDVLPGQLRFMCEREGLEVRSIRRLRIGALSLARLPLGEWRYLGLHERF

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

5.4.99.21

Gene Ontology (GO)

6

GO:0160138 Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA.
GO:0003723 Binding to an RNA molecule or a portion thereof.
GO:0001522 The intramolecular conversion of uridine to pseudouridine within an RNA molecule.
GO:0006396 Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
GO:0009982 Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
GO:0009451 The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
5	64	ProSiteProfiles	PS50889	S4 RNA-binding domain profile.
60	236	CDD	cd02555	PSSA_1
65	235	SUPERFAMILY	SSF55120	Pseudouridine synthase
65	235	InterPro	IPR020103	Pseudouridine synthase, catalytic domain superfamily
62	235	FunFam	G3DSA:3.30.2350.10:FF:000026	RNA-binding protein S4
2	60	FunFam	G3DSA:3.10.290.10:FF:000034	RNA-binding protein S4
6	45	Pfam	PF01479	S4 domain
6	45	InterPro	IPR002942	RNA-binding S4 domain
5	61	CDD	cd00165	S4
62	235	Gene3D	G3DSA:3.30.2350.10	Pseudouridine synthase
2	52	Gene3D	G3DSA:3.10.290.10	-
2	52	InterPro	IPR036986	RNA-binding S4 domain superfamily
5	49	SUPERFAMILY	SSF55174	Alpha-L RNA-binding motif
3	231	PANTHER	PTHR47683	PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED
5	65	SMART	SM00363	s4_6
5	65	InterPro	IPR002942	RNA-binding S4 domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1110	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.67

PA1110