Protein profile

PA1115

hypothetical protein

Genome: NC_002516.2

Gene: PA1115 Structure source: AlphaFold UniProt Q9I4M0
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Amino acids 774
Annotations 2
Features 26
PDB binders 1
Druggability 0.926

Overview

Basic information about this protein and its source genome.

Accession
PA1115
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1115
Status
annotated
Amino acids
774
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.926
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
108 130 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 547 PANTHER PTHR47371 LIPOTEICHOIC ACID SYNTHASE
110 130 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
55 60 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
84 109 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
137 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
11 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
142 158 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
37 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
222 534 SUPERFAMILY SSF53649 Alkaline phosphatase-like
222 534 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily
224 501 Pfam PF00884 Sulfatase
224 501 InterPro IPR000917 Sulfatase, N-terminal
61 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
159 774 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
59 81 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 52 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
28 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
219 503 Gene3D G3DSA:3.40.720.10 Alkaline Phosphatase, subunit A
219 503 InterPro IPR017850 Alkaline-phosphatase-like, core domain superfamily
131 141 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
223 500 CDD cd16015 LTA_synthase
23 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1115
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.608

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

5 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
GP9
4UOR
Q8Y8H6 170.1 Da LogP -2.82 TPSA 112.9 ✓ Ro5 ✓ Clean C(C(COP(=O)([O-])[O-])O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.