Protein profile

PA1119

hypothetical protein

Genome: NC_002516.2

Gene: PA1119 yfiB Structure source: Experimental + AlphaFold UniProt Q9I4L6
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Amino acids 168
Annotations 4
Features 25
PDB binders 6
Druggability 0.834

Overview

Basic information about this protein and its source genome.

Accession
PA1119
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1119 yfiB
Status
annotated
Amino acids
168
Structure source
Experimental + AlphaFold
GO
GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.834
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
65 159 Pfam PF00691 OmpA family
65 159 InterPro IPR006665 OmpA-like domain
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
63 165 CDD cd07185 OmpA_C-like
63 165 InterPro IPR006665 OmpA-like domain
46 166 PANTHER PTHR30329 STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX
95 110 PRINTS PR01021 OMPA domain signature
95 110 InterPro IPR006664 Outer membrane protein, bacterial
65 87 PRINTS PR01021 OMPA domain signature
65 87 InterPro IPR006664 Outer membrane protein, bacterial
110 126 PRINTS PR01021 OMPA domain signature
110 126 InterPro IPR006664 Outer membrane protein, bacterial
27 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
1 26 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
53 168 ProSiteProfiles PS51123 OmpA-like domain profile.
53 168 InterPro IPR006665 OmpA-like domain
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
52 165 SUPERFAMILY SSF103088 OmpA-like
52 165 InterPro IPR036737 OmpA-like domain superfamily
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
34 168 Gene3D G3DSA:3.30.1330.60 -
34 168 InterPro IPR036737 OmpA-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

10 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4ZHW
X-ray 1.39 Å A
100.0% 1-168
PDBe RCSB PDBj File
Viewing
PDB 4ZHV
X-ray 1.58 Å A,B
100.0% 1-168
PDBe RCSB PDBj File
Loaded
PDB 6IKJ
X-ray 1.76 Å A,B
100.0% 1-168
PDBe RCSB PDBj File
Loaded
PDB 4ZHY
X-ray 1.97 Å B
100.0% 1-168
PDBe RCSB PDBj File
Loaded
PDB 6IKK
X-ray 2.19 Å A,C
100.0% 1-168
PDBe RCSB PDBj File
Loaded
PDB 6IKI
X-ray 2.20 Å A,B
100.0% 1-168
PDBe RCSB PDBj File
Loaded
PDB 5EB1
X-ray 1.80 Å B,D
80.4% 34-168
PDBe RCSB PDBj File
Loaded
PDB 5EAZ
X-ray 2.15 Å A,B,C,D
80.4% 34-168
PDBe RCSB PDBj File
Loaded
PDB 5EB0
X-ray 2.80 Å A,B
80.4% 34-168
PDBe RCSB PDBj File
Loaded
PDB 5Y61
X-ray 2.99 Å B,D
80.4% 34-168
PDBe RCSB PDBj File
Loaded
AlphaFold PA1119
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.834
1 0.493

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
5GP
5Y61 2.99 Å Open crystal
363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.