Protein target profile

PA1124

deoxyguanosinetriphosphate triphosphohydrolase

Genome: NC_002516.2

Gene: PA1124 dgt 3D evidence: Experimental + AlphaFold DB model UniProt Q9I4L1
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Length 498
Pocket druggability 0.728
EC / GO 1 / 4
Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

4 signals

Strengths

No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Strong predicted binding pocket FPocket selected-pocket score 0.73. This is a computational pocket signal, not binding validation. Structure available Experimental + AlphaFold DB model

Risks / watch

No major risk signal surfaced in the loaded evidence.

Missing evidence

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.
How to read this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal TPW pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Overview

Basic information about this protein and its source genome.

Accession
PA1124
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1124 dgt
Status
annotated
Amino acids
498
3D evidence
Experimental + AlphaFold DB model
EC
3.1.5.1
GO
GO:0008832 Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. GO:0000287 Binding to a magnesium (Mg) ion. GO:0006203 The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. GO:0016793 Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected pocket evidence

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.728
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPGAVDFKERISRQRPHDRETYGHAGNTDLQDIVYQLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLFRQLGPRAAEVGLDGLEGALESLVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALFERRIPPGQGDGLLQQRMLTDLKHFEGNAQAIRLVVKLLRLNLTYTQTAGLLKYVRPAYEPKPDKAAANHYLNKKPGFYLSEEAFVDELRRVLGMRPGTRHPVAYIMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAVHHSPDAPIPGDADNMSFQRMVDYSLEKAEREPINKVSEFFIRLRVKMIHPLVQHAAQQFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRLPAEEFQALAEGRQAAAPHPQLLVRRLPSQQIKAYLEAMKGVAEDPLQRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALSAL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008832 Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0006203 The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
  • GO:0016793 Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
2 498 Hamap MF_00030 Deoxyguanosinetriphosphate triphosphohydrolase [dgt].
2 498 InterPro IPR020779 dNTP triphosphohydrolase, type 1
151 251 Gene3D G3DSA:1.10.3210.10 Hypothetical protein af1432
36 496 NCBIfam TIGR01353 dNTP triphosphohydrolase
36 496 InterPro IPR006261 dNTP triphosphohydrolase
3 150 Gene3D G3DSA:1.10.3210.10 Hypothetical protein af1432
150 251 FunFam G3DSA:1.10.3210.10:FF:000010 Deoxyguanosinetriphosphate triphosphohydrolase
71 262 ProSiteProfiles PS51831 HD domain profile.
71 262 InterPro IPR006674 HD domain
36 475 PANTHER PTHR11373 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE
71 137 Pfam PF01966 HD domain
71 137 InterPro IPR006674 HD domain
36 493 SUPERFAMILY SSF109604 HD-domain/PDEase-like
69 135 CDD cd00077 HDc
69 135 InterPro IPR003607 HD/PDEase domain
252 385 Gene3D G3DSA:1.10.3410.10 putative deoxyguanosinetriphosphate triphosphohydrolase like domain
252 385 InterPro IPR023293 Deoxyguanosinetriphosphate triphosphohydrolase, central domain superfamily
67 271 SMART SM00471 hd_13
67 271 InterPro IPR003607 HD/PDEase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7W1F
X-ray 2.90 Å A,B,C
100.0% 1-498
PDBe RCSB PDBj File
Viewing
AlphaFold DB PA1124
AlphaFold DB — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.728
9 0.215

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.1 0.674
2 3.45 0.125
3 3.41 0.122
4 2.07 0.046
5 2.02 0.044