Protein profile

PA1129

glutathione transferase FosA

Genome: NC_002516.2

Gene: PA1129 fosA Structure source: Experimental + AlphaFold UniProt Q9I4K6
Export view
Amino acids 135
Annotations 5
Features 10
PDB binders 6
Druggability 0.676

Overview

Basic information about this protein and its source genome.

Accession
PA1129
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1129 fosA
Status
annotated
Amino acids
135
Structure source
Experimental + AlphaFold
EC
2.5.1.18
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004364 Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0046872 Binding to a metal ion. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.676
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MLTGLNHLTLAVADLPASIAFYRDLLGFRLEARWDQGAYLELGSLWLCLSREPQYGGPAADYTHYAFGIAAADFARFAAQLRAHGVREWKQNRSEGDSFYFLDPDGHRLEAHVGDLRSRLAACRQAPYAGMRFAD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004364 Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
  • GO:0046872 Binding to a metal ion.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
4 114 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
4 114 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain
1 127 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
1 127 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
4 125 CDD cd07244 FosA
4 110 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
4 110 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
1 135 Gene3D G3DSA:3.10.180.10 -
1 135 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
2 112 PANTHER PTHR21366 GLYOXALASE FAMILY PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1NKI
X-ray 0.95 Å A,B
100.0% 1-135
PDBe RCSB PDBj File
Viewing
PDB 1LQP
X-ray 1.19 Å A,B
100.0% 1-135
PDBe RCSB PDBj File
Loaded
PDB 1LQK
X-ray 1.35 Å A,B
100.0% 1-135
PDBe RCSB PDBj File
Loaded
PDB 1LQO
X-ray 2.00 Å A,B
100.0% 1-135
PDBe RCSB PDBj File
Loaded
PDB 1NNR
X-ray 2.25 Å A,B
100.0% 1-135
PDBe RCSB PDBj File
Loaded
AlphaFold PA1129
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.676
3 0.289

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.92 0.478
2 3.38 0.121
3 2.28 0.057

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

26 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
FCN
1LQP 1.19 Å Open crystal
138.1 Da LogP -0.09 TPSA 70.1 ✓ Ro5 ✓ Clean C[C@H]1[C@H](O1)P(=O)(O)O
PPF
1NKI 0.95 Å Open crystal
126.0 Da LogP -0.16 TPSA 94.8 ✓ Ro5 ✓ Clean C(=O)(O)P(=O)(O)O
TL
1LQO 2.00 Å Open crystal
204.4 Da LogP -0.38 TPSA 0.0 ✓ Ro5 ✓ Clean [Tl+]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.