Protein profile

PA1140

hypothetical protein

Genome: NC_002516.2

Gene: PA1140 Structure source: Experimental + AlphaFold UniProt Q9I4J5
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Amino acids 278
Annotations 3
Features 19
PDB binders 1
Druggability 0.86

Overview

Basic information about this protein and its source genome.

Accession
PA1140
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1140
Status
annotated
Amino acids
278
Structure source
Experimental + AlphaFold
GO
GO:0071522 Catalysis of the reaction: (S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4+. GO:0006145 The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0010136 The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.86
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0071522 Catalysis of the reaction: (S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4+.
  • GO:0006145 The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
  • GO:0010136 The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
3 271 PANTHER PTHR34571 (S)-UREIDOGLYCINE AMINOHYDROLASE
3 271 InterPro IPR017627 (S)-ureidoglycine aminohydrolase
27 268 Gene3D G3DSA:2.60.120.10 Jelly Rolls
27 268 InterPro IPR014710 RmlC-like jelly roll fold
42 160 CDD cd02211 cupin_UGlyAH_N
42 160 InterPro IPR044704 (S)-ureidoglycine aminohydrolase, N-terminal cupin domain
10 272 SUPERFAMILY SSF51182 RmlC-like cupins
10 272 InterPro IPR011051 RmlC-like cupin domain superfamily
176 268 CDD cd02212 cupin_UGlyAH_C
176 268 InterPro IPR044697 (S)-ureidoglycine aminohydrolase, C-terminal cupin domain
195 252 Pfam PF07883 Cupin domain
195 252 InterPro IPR013096 Cupin 2, conserved barrel
72 141 Pfam PF07883 Cupin domain
72 141 InterPro IPR013096 Cupin 2, conserved barrel
41 166 Gene3D G3DSA:2.60.120.10 Jelly Rolls
41 166 InterPro IPR014710 RmlC-like jelly roll fold
6 272 NCBIfam NF040771 bifunctional allantoicase/(S)-ureidoglycine aminohydrolase, UGLYAH2 family
19 271 NCBIfam TIGR03214 (S)-ureidoglycine aminohydrolase
19 271 InterPro IPR017627 (S)-ureidoglycine aminohydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1SQ4
X-ray 2.70 Å A,B
100.0% 1-278
PDBe RCSB PDBj File
Viewing
AlphaFold PA1140
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.86

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.02 0.161
2 1.98 0.042
3 1.4 0.018
4 1.08 0.007
5 1.02 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
UGY
4E2S
Q8GXV5 133.1 Da LogP -1.98 TPSA 118.4 ✓ Ro5 ✓ Clean [C@H](C(=O)O)(N)NC(=O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.