Protein profile

PA1141

transcriptional regulator

Genome: NC_002516.2

Gene: PA1141 Structure source: AlphaFold UniProt Q9I4J4
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Amino acids 300
Annotations 3
Features 22
PDB binders 6
Druggability 0.958

Overview

Basic information about this protein and its source genome.

Accession
PA1141
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1141
Status
annotated
Amino acids
300
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.958
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
170 263 FunFam G3DSA:3.40.190.10:FF:000069 HTH-type transcriptional regulator lrhA
11 294 PANTHER PTHR30579 TRANSCRIPTIONAL REGULATOR
9 94 Gene3D G3DSA:1.10.10.10 -
9 94 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
104 270 Gene3D G3DSA:3.40.190.10 -
40 50 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
40 50 InterPro IPR000847 Transcription regulator HTH, LysR
50 61 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
50 61 InterPro IPR000847 Transcription regulator HTH, LysR
29 40 PRINTS PR00039 LysR bacterial regulatory protein HTH signature
29 40 InterPro IPR000847 Transcription regulator HTH, LysR
12 95 FunFam G3DSA:1.10.10.10:FF:000001 LysR family transcriptional regulator
101 287 Pfam PF03466 LysR substrate binding domain
101 287 InterPro IPR005119 LysR, substrate-binding
14 72 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
14 72 InterPro IPR000847 Transcription regulator HTH, LysR
170 263 Gene3D G3DSA:3.40.190.10 -
12 69 ProSiteProfiles PS50931 LysR-type HTH domain profile.
12 69 InterPro IPR000847 Transcription regulator HTH, LysR
6 119 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 119 InterPro IPR036390 Winged helix DNA-binding domain superfamily
101 291 SUPERFAMILY SSF53850 Periplasmic binding protein-like II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1141
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.958
5 0.836

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
1PS
6G1B
Q8NP91 201.2 Da LogP -0.09 TPSA 61.1 ✓ Ro5 ✓ Clean c1cc[n+](cc1)CCCS(=O)(=O)[O-]
BEZ
2F7A
O68014 122.1 Da LogP 1.38 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)C(=O)O
CCU
3GLB
P07774 142.1 Da LogP 0.27 TPSA 74.6 ✓ Ro5 ✓ Clean C(=C/C(=O)O)/C=C\C(=O)O
FOR
6G1D
Q8NP91 30.0 Da LogP -0.18 TPSA 17.1 ✓ Ro5 ✓ Clean C=O
MLI
4IHS
O68014 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]
PEO
6G1B
Q8NP91 34.0 Da LogP 0.02 TPSA 40.5 ✓ Ro5 ✓ Clean OO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.