Protein profile

PA1143

hypothetical protein

Genome: NC_002516.2

Gene: PA1143 Structure source: AlphaFold UniProt Q9I4J2
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Amino acids 217
Annotations 3
Features 12
PDB binders 0
Druggability 0.796

Overview

Basic information about this protein and its source genome.

Accession
PA1143
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1143
Status
annotated
Amino acids
217
Structure source
AlphaFold
EC
3.1.3.15
GO
GO:0004401 Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.796
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0004401 Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
3 199 CDD cd02612 HAD_PGPPase
3 216 PANTHER PTHR43344 PHOSPHOSERINE PHOSPHATASE
4 187 Pfam PF12710 haloacid dehalogenase-like hydrolase
15 88 Gene3D G3DSA:1.20.1440.100 -
79 214 FunFam G3DSA:3.40.50.1000:FF:000025 HAD hydrolase, family IB
3 190 NCBIfam TIGR01488 HAD-IB family phosphatase
2 205 SUPERFAMILY SSF56784 HAD-like
2 205 InterPro IPR036412 HAD-like superfamily
3 201 NCBIfam TIGR01490 HAD-IB family hydrolase
3 201 InterPro IPR006385 HAD-superfamily hydrolase, subfamily IB, SerB1-like
3 213 Gene3D G3DSA:3.40.50.1000 -
3 213 InterPro IPR023214 HAD superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1143
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.796
4 0.212