Protein profile

PA1150

pyocin-S2

Genome: NC_002516.2

Gene: PA1150 pys2 Structure source: Experimental + AlphaFold UniProt Q06584
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Amino acids 689
Annotations 9
Features 35
PDB binders 1
Druggability 0.593

Overview

Basic information about this protein and its source genome.

Accession
PA1150
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1150 pys2
Status
annotated
Amino acids
689
Structure source
Experimental + AlphaFold
EC
3.1.-.-
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion. GO:0005102 Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. GO:0019835 The rupture of cell membranes and the loss of cytoplasm. GO:0042742 Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.593
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.
  • GO:0005102 Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
  • GO:0019835 The rupture of cell membranes and the loss of cytoplasm.
  • GO:0042742 Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
  • GO:0031640 Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
  • GO:0009617 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records
Show feature table
Start End DB Term Name
648 685 CDD cd00085 HNHc
648 685 InterPro IPR003615 HNH nuclease
415 554 Pfam PF06958 S-type Pyocin
415 554 InterPro IPR016128 Pyosin/cloacin translocation domain
555 685 SUPERFAMILY SSF54060 His-Me finger endonucleases
555 685 InterPro IPR044925 His-Me finger superfamily
627 682 SMART SM00507 HNH_5
627 682 InterPro IPR003615 HNH nuclease
283 303 Coils Coil Coil
584 605 PRINTS PR01300 Pyocin S killer protein signature
584 605 InterPro IPR003060 Pyocin S killer protein
397 420 PRINTS PR01300 Pyocin S killer protein signature
397 420 InterPro IPR003060 Pyocin S killer protein
551 570 PRINTS PR01300 Pyocin S killer protein signature
551 570 InterPro IPR003060 Pyocin S killer protein
448 466 PRINTS PR01300 Pyocin S killer protein signature
448 466 InterPro IPR003060 Pyocin S killer protein
629 646 PRINTS PR01300 Pyocin S killer protein signature
629 646 InterPro IPR003060 Pyocin S killer protein
314 335 PRINTS PR01300 Pyocin S killer protein signature
314 335 InterPro IPR003060 Pyocin S killer protein
362 380 PRINTS PR01300 Pyocin S killer protein signature
362 380 InterPro IPR003060 Pyocin S killer protein
606 625 PRINTS PR01300 Pyocin S killer protein signature
606 625 InterPro IPR003060 Pyocin S killer protein
667 686 PRINTS PR01300 Pyocin S killer protein signature
667 686 InterPro IPR003060 Pyocin S killer protein
341 361 PRINTS PR01300 Pyocin S killer protein signature
341 361 InterPro IPR003060 Pyocin S killer protein
242 262 Coils Coil Coil
556 689 Gene3D G3DSA:3.90.540.10 Colicin/pyocin, DNase domain
556 689 InterPro IPR037146 Colicin/pyocin, DNase domain superfamily
169 203 Coils Coil Coil
322 584 SUPERFAMILY SSF69369 Cloacin translocation domain
322 584 InterPro IPR036302 Pyosin/cloacin translocation domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5ODW
X-ray 2.80 Å C,D
30.3% 1-209
PDBe RCSB PDBj File
Viewing
PDB 4QKO
X-ray 1.80 Å B,D,F,H
19.4% 556-689
PDBe RCSB PDBj File
Loaded
AlphaFold PA1150
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

19 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MLA
2VLN
P09883 104.1 Da LogP -0.45 TPSA 74.6 ✓ Ro5 ✓ Clean C(C(=O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.