Protein profile

PA1151

pyocin-S2 immunity protein

Genome: NC_002516.2

Gene: PA1151 imm2 Structure source: Experimental + AlphaFold UniProt Q06579
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Amino acids 87
Annotations 2
Features 15
PDB binders 0
Druggability 0.593

Overview

Basic information about this protein and its source genome.

Accession
PA1151
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1151 imm2
Status
annotated
Amino acids
87
Structure source
Experimental + AlphaFold
GO
GO:0015643 Binding to a toxic substance, a poisonous substance that causes damage to biological systems. GO:0030153 A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.593
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0015643 Binding to a toxic substance, a poisonous substance that causes damage to biological systems.
  • GO:0030153 A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 87 FunFam G3DSA:1.10.1200.20:FF:000001 Colicin-E9 immunity protein
2 85 CDD cd16363 Col_Im_like
2 85 InterPro IPR000290 Colicin immunity protein/pyocin immunity protein
41 57 PRINTS PR01299 Colicin E2 (pyocin) immunity protein signature
41 57 InterPro IPR000290 Colicin immunity protein/pyocin immunity protein
64 85 PRINTS PR01299 Colicin E2 (pyocin) immunity protein signature
64 85 InterPro IPR000290 Colicin immunity protein/pyocin immunity protein
2 20 PRINTS PR01299 Colicin E2 (pyocin) immunity protein signature
2 20 InterPro IPR000290 Colicin immunity protein/pyocin immunity protein
1 85 Pfam PF01320 Colicin immunity protein / pyocin immunity protein
1 85 InterPro IPR000290 Colicin immunity protein/pyocin immunity protein
1 86 SUPERFAMILY SSF47345 Colicin E immunity proteins
1 86 InterPro IPR035900 Colicin E immunity protein superfamily
1 87 Gene3D G3DSA:1.10.1200.20 Colicin E immunity protein
1 87 InterPro IPR035900 Colicin E immunity protein superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4QKO
X-ray 1.80 Å A,C,E,G
100.0% 1-87
PDBe RCSB PDBj File
Viewing
AlphaFold PA1151
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.593
2 0.412

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.07 0.102