Protein profile

PA1163

glycosyl transferase

Genome: NC_002516.2

Gene: PA1163 ndvB Structure source: AlphaFold UniProt Q9I4H4
Export view
Amino acids 869
Annotations 7
Features 42
PDB binders 1
Druggability 0.854

Overview

Basic information about this protein and its source genome.

Accession
PA1163
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1163 ndvB
Status
annotated
Amino acids
869
Structure source
AlphaFold
EC
2.4.1.336
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0006075 The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds. GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.854
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0006075 The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
  • GO:0030244 The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
684 706 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
312 331 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
362 366 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
39 302 SUPERFAMILY SSF51445 (Trans)glycosidases
39 302 InterPro IPR017853 Glycoside hydrolase superfamily
412 633 FunFam G3DSA:3.90.550.10:FF:000164 Beta-(1-3)-glucosyl transferase
405 662 SUPERFAMILY SSF53448 Nucleotide-diphospho-sugar transferases
405 662 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
718 740 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
707 717 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
421 649 Pfam PF13641 Glycosyltransferase like family 2
775 802 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
718 740 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
367 391 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 311 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
344 361 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
827 850 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
827 849 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
333 343 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
752 774 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
821 826 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
851 869 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
741 751 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
392 683 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
752 774 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
344 361 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
803 820 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
412 633 Gene3D G3DSA:3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
412 633 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
376 398 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
223 236 ProSitePatterns PS00587 Glycosyl hydrolases family 17 signature.
223 236 InterPro IPR000490 Glycoside hydrolase family 17
10 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
681 703 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 849 PANTHER PTHR43867 CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]
196 303 Gene3D G3DSA:3.20.20.80 Glycosidases
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
312 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
803 822 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1163
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.854

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
GDD
6YV9
A3MTD6 605.3 Da LogP -4.63 TPSA 331.7 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.