Protein profile

PA1169

arachidonate 15-lipoxygenase

Genome: NC_002516.2

Gene: PA1169 loxA Structure source: Experimental + AlphaFold UniProt Q9I4G8
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Amino acids 685
Annotations 10
Features 28
PDB binders 7
Druggability 0.597

Overview

Basic information about this protein and its source genome.

Accession
PA1169
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1169 loxA
Status
annotated
Amino acids
685
Structure source
Experimental + AlphaFold
EC
1.13.11.- 1.13.11.33
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0050473 Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. GO:0016165 Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. GO:0046872 Binding to a metal ion. GO:0016702 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
33.425
Human E-value
1.2999999999999999e-40
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.597
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 8 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

8
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0050473 Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
  • GO:0016165 Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
  • GO:0046872 Binding to a metal ion.
  • GO:0016702 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
  • GO:0006631 The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
  • GO:0034440 The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
140 160 Coils Coil Coil
251 374 Gene3D G3DSA:3.10.450.60 -
392 412 PRINTS PR00087 Lipoxygenase signature
392 412 InterPro IPR013819 Lipoxygenase, C-terminal
354 371 PRINTS PR00087 Lipoxygenase signature
354 371 InterPro IPR013819 Lipoxygenase, C-terminal
372 389 PRINTS PR00087 Lipoxygenase signature
372 389 InterPro IPR013819 Lipoxygenase, C-terminal
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
218 685 PANTHER PTHR11771 LIPOXYGENASE
218 685 InterPro IPR000907 Lipoxygenase
195 685 SUPERFAMILY SSF48484 Lipoxigenase
195 685 InterPro IPR036226 Lipoxigenase, C-terminal domain superfamily
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
646 666 Coils Coil Coil
399 409 ProSitePatterns PS00081 Lipoxygenases iron-binding region signature 2.
399 409 InterPro IPR020834 Lipoxygenase, conserved site
227 667 Pfam PF00305 Lipoxygenase
227 667 InterPro IPR013819 Lipoxygenase, C-terminal
6 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
372 386 ProSitePatterns PS00711 Lipoxygenases iron-binding region signature 1.
372 386 InterPro IPR020833 Lipoxygenase, iron binding site
122 685 ProSiteProfiles PS51393 Lipoxygenase iron-binding catalytic domain profile.
122 685 InterPro IPR013819 Lipoxygenase, C-terminal
20 685 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
196 682 Gene3D G3DSA:1.20.245.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5IR4
X-ray 1.48 Å A
98.8% 9-685
PDBe RCSB PDBj File
Viewing
PDB 5IR5
X-ray 1.90 Å A
98.8% 9-685
PDBe RCSB PDBj File
Loaded
AlphaFold PA1169
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.597

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 51.72 0.982
2 26.08 0.91
3 7.81 0.414
4 5.27 0.247
5 4.62 0.2

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

81 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
ZPE
5IR4 1.48 Å Open crystal
687.9 Da LogP 10.05 TPSA 134.4 2 viol. ✓ Clean CCCCCCCCC=CCCCC(=O)O[C@H](COC(=O)CCCCCCCCC/C=C\…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.