Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1173
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: napB PA1173
Status: annotated
Amino acids: 163
Structure source: AlphaFold

GO

GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0046872 Binding to a metal ion. GO:0009061 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.648

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MKPLLTALLLVLLGAPAAFAADLGYPLDAPAPDGRRPGGTLAESRPAPPLAAEENKDLKRERNYPEQPPTIPHSIVGYRIDKDSNKCLSCHSRANSARTQAVMISITHYMDRDGQPLAAVSPRRYFCVQCHVPQQDVKPLVDNRFENIDQILEKEAANAARKP

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
GO:0046872 Binding to a metal ion.
GO:0009061 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
1	152	PANTHER	PTHR38604	PERIPLASMIC NITRATE REDUCTASE, ELECTRON TRANSFER SUBUNIT
1	152	InterPro	IPR005591	Nitrate reductase cytochrome c-type subunit NapB
1	20	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
16	20	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
44	153	SUPERFAMILY	SSF48695	Multiheme cytochromes
44	153	InterPro	IPR036280	Multiheme cytochrome superfamily
21	163	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
66	132	FunFam	G3DSA:1.10.1130.10:FF:000001	Periplasmic nitrate reductase, electron transfer subunit
1	3	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
3	162	PIRSF	PIRSF006105	NapB
3	162	InterPro	IPR005591	Nitrate reductase cytochrome c-type subunit NapB
50	66	MobiDBLite	mobidb-lite	consensus disorder prediction
1	20	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
40	146	Pfam	PF03892	Nitrate reductase cytochrome c-type subunit (NapB)
40	146	InterPro	IPR005591	Nitrate reductase cytochrome c-type subunit NapB
66	132	Gene3D	G3DSA:1.10.1130.10	Flavocytochrome C3; Chain A
1	20	Phobius	SIGNAL_PEPTIDE	Signal peptide region
31	73	MobiDBLite	mobidb-lite	consensus disorder prediction
4	15	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1173	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.648

PA1173