Protein profile

PA1177

nitrate reductase protein NapE

Genome: NC_002516.2

Gene: PA1177 napE Structure source: AlphaFold UniProt Q9I4G0

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Amino acids 55

Annotations 0

Features 8

PDB binders 0

Druggability 0.93

Overview

Basic information about this protein and its source genome.

Accession: PA1177
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1177 napE
Status: annotated
Amino acids: 55
Structure source: AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.93

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
11	52	NCBIfam	TIGR02973	periplasmic nitrate reductase, NapE protein
11	52	InterPro	IPR004448	Nitrate reductas, NapE, periplasmic
45	55	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17	39	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
17	44	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	16	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2	53	Pfam	PF06796	Periplasmic nitrate reductase protein NapE
2	53	InterPro	IPR010649	Nitrate/trimethylamine N-oxide reductase NapE/TorE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1177	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.93
1				0.529