Protein profile

PA1178

PhoP/Q and low Mg2+ inducible outer membrane protein H1

Genome: NC_002516.2

Gene: PAERUG_P19_London_7_VIM_2_05_10_02134 GNQ48_03675 PA1178 DT376_23360 CAZ10_07205 L4V69_24940 IPC1295_19605 GUL26_05925 oprH Structure source: AlphaFold UniProt Q51486 UniProt G3XD11
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Amino acids 200
Annotations 2
Features 11
PDB binders 0
Druggability 0.628

Overview

Basic information about this protein and its source genome.

Accession
PA1178
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PAERUG_P19_London_7_VIM_2_05_10_02134 GNQ48_03675 PA1178 DT376_23360 CAZ10_07205 L4V69_24940 IPC1295_19605 GUL26_05925 oprH
Status
annotated
Amino acids
200
Structure source
AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0001530 Binding to a lipopolysaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.628
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0001530 Binding to a lipopolysaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
23 200 Gene3D G3DSA:2.40.160.20 -
23 200 FunFam G3DSA:2.40.160.20:FF:000004 Outer membrane protein H1
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
45 200 SUPERFAMILY SSF56925 OMPA-like
45 200 InterPro IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel
23 200 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1178
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.628