Protein profile

PA1182

transcriptional regulator

Genome: NC_002516.2

Gene: PA1182 Structure source: AlphaFold UniProt Q9I4F6
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Amino acids 333
Annotations 4
Features 16
PDB binders 1
Druggability 0.41

Overview

Basic information about this protein and its source genome.

Accession
PA1182
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1182
Status
annotated
Amino acids
333
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.41
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
22 203 Pfam PF12625 Arabinose-binding domain of AraC transcription regulator, N-term
22 203 InterPro IPR032687 HTH-type transcriptional regulator AraC-type, N-terminal
233 330 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
233 330 InterPro IPR018060 DNA binding HTH domain, AraC-type
245 328 SMART SM00342 aracneu4
245 328 InterPro IPR018060 DNA binding HTH domain, AraC-type
297 312 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
297 312 InterPro IPR020449 Transcription regulator HTH, AraC- type
312 328 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
312 328 InterPro IPR020449 Transcription regulator HTH, AraC- type
281 330 SUPERFAMILY SSF46689 Homeodomain-like
281 330 InterPro IPR009057 Homeobox-like domain superfamily
228 333 Gene3D G3DSA:1.10.10.60 -
252 329 Pfam PF12833 Helix-turn-helix domain
252 329 InterPro IPR018060 DNA binding HTH domain, AraC-type
1 332 PANTHER PTHR47894 HTH-TYPE TRANSCRIPTIONAL REGULATOR GADX

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1182
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.41
3 0.384

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
DKA
6XIU
P16114 172.3 Da LogP 3.21 TPSA 37.3 ✓ Ro5 ✓ Clean CCCCCCCCCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.