Protein profile

PA1195

hypothetical protein

Genome: NC_002516.2

Gene: PA1195 Structure source: Experimental + AlphaFold UniProt Q9I4E3
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Amino acids 254
Annotations 7
Features 5
PDB binders 9
Druggability 0.433

Overview

Basic information about this protein and its source genome.

Accession
PA1195
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1195
Status
annotated
Amino acids
254
Structure source
Experimental + AlphaFold
EC
3.5.3.18
GO
GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents. GO:0016403 Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. GO:0046872 Binding to a metal ion. GO:0006525 The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0000052 The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. GO:0045429 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
30.827
Human E-value
3.15e-29
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.433
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents.
  • GO:0016403 Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
  • GO:0046872 Binding to a metal ion.
  • GO:0006525 The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
  • GO:0000052 The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
  • GO:0045429 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 254 Gene3D G3DSA:3.75.10.10 -
2 253 PANTHER PTHR12737 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE
2 253 InterPro IPR033199 Dimethylarginine dimethylaminohydrolase
2 253 SUPERFAMILY SSF55909 Pentein
29 250 Pfam PF19420 N,N dimethylarginine dimethylhydrolase, eukaryotic

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1H70
X-ray 1.80 Å A
100.0% 1-254
PDBe RCSB PDBj File
Viewing
PDB 3RHY
X-ray 2.18 Å A,B
100.0% 1-254
PDBe RCSB PDBj File
Loaded
PDB 3BPB
X-ray 2.81 Å A,B
100.0% 1-254
PDBe RCSB PDBj File
Loaded
AlphaFold PA1195
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.433
3 0.351

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.24 0.716
2 5.93 0.291
3 2.91 0.093
4 2.72 0.081

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

72 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
CIR
1H70 1.80 Å Open crystal
175.2 Da LogP -1.15 TPSA 118.4 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CNC(=O)N
HM3
3RHY 2.18 Å Open crystal
143.6 Da LogP 1.23 TPSA 33.1 ✓ Ro5 ✓ Clean c1cnc(cc1Cl)CO
SMZ
3BPB 2.81 Å Open crystal
205.3 Da LogP 0.07 TPSA 99.2 ✓ Ro5 ✓ Clean [H]/N=C(/NCCC[C@@H](C(=O)O)N)\SC

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.