Protein profile

PA1232

hypothetical protein

Genome: NC_002516.2

Gene: PA1232 Structure source: AlphaFold UniProt Q9I4A6

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Amino acids 679

Annotations 3

Features 42

PDB binders 0

Druggability 0.733

Overview

Basic information about this protein and its source genome.

Accession: PA1232
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1232
Status: annotated
Amino acids: 679
Structure source: AlphaFold

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.733

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MAASASGGRDWYAALPLPWRTDSLGYVLRSIGAAALALGLGLYLQLDSPFSAASTVLLLINPVQGAVVGKGWWRAVGTLVGTLAAFVLTALFAQKMLLFVVALGFWLGLCVGVMSLVRHFYATAAVVAGYTVCLALGPAMVEPEAAFEHIVTRASAVIVGVCCLSLVTVLFSRRTVSGRVRQRLVSLCAATLALVAARHAGAADGELERRRRTLAGEVYAVDDLLGVGRAESRVLSAALPAIRGGLAALFSTLMEFRFAGETHWARCLAERGLALPMADDLRLLGGQLERGELDFAGAARRLASLRGRLAAIRRGLPTDQADACREGLFMERLDEQLDDLQAALRGFARLDGRAPADVRPAAFHRHYREALRNGARAWLAMLVGGALWFLSGWDQGPTLLAVLGPYCTLLAASPFPAEGTRNFIRGTLYAIPAALLCKFLLLPLINGFPLLLLCLAFFWSFGIQATTVPRRALQGIAYLIAFNTLVATGNLARFDFGDFANQSCAWVLALCISLLVYRLLPKDLERHSASLLDHLRRETLALLRRRAGFDAHAWQARQQHRIAQLGALHGMEHPRSALALRLGFVSLQLGRESRRLWRALAGLDPAAAEARWIERALRAIAVRHRDPPLAARHARRAGARLAAAGEWRLAAILTDLAWLLRAYSQSVSSDGAQHGEKTS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records

Show feature table

Start	End	DB	Term	Name
69	74	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50	68	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
26	44	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
173	183	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
394	398	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
153	172	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
45	49	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
499	521	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
375	393	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
234	256	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
25	44	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
440	462	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
374	393	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
423	442	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
475	493	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
469	474	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
71	93	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
151	173	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
119	141	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
330	350	Coils	Coil	Coil
184	201	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
494	498	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24	664	Pfam	PF04632	Fusaric acid resistance protein family
24	664	InterPro	IPR006726	Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein
443	447	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
257	374	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
32	233	PANTHER	PTHR30509	P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED
142	152	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
417	422	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
499	520	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
475	494	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
94	98	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
399	416	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
99	117	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
521	679	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
75	93	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
98	117	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
448	468	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
124	141	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	25	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
202	233	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118	123	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1232	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.733
1				0.667