Protein profile

PA1237

multidrug resistance efflux pump

Genome: NC_002516.2

Gene: PA1237 Structure source: AlphaFold UniProt Q9I4A1
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Amino acids 383
Annotations 0
Features 21
PDB binders 0
Druggability 0.88

Overview

Basic information about this protein and its source genome.

Accession
PA1237
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1237
Status
annotated
Amino acids
383
Structure source
AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.88
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
65 109 Pfam PF13533 Biotin-lipoyl like
65 109 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
196 296 SUPERFAMILY SSF111369 HlyD-like secretion proteins
177 197 Coils Coil Coil
256 277 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
75 95 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
288 312 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
360 375 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
63 137 SUPERFAMILY SSF111369 HlyD-like secretion proteins
205 232 Coils Coil Coil
47 383 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 46 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 376 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
64 129 Gene3D G3DSA:2.40.50.100 -
245 363 Pfam PF13437 HlyD family secretion protein
258 380 Gene3D G3DSA:2.40.30.170 -
174 205 MobiDBLite mobidb-lite consensus disorder prediction
1 26 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
104 145 Coils Coil Coil
133 208 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
27 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1237
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.88