Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1242
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1242
Status: annotated
Amino acids: 590
Structure source: AlphaFold

GO

GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0071977 Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium. GO:1900377 Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. GO:1900232 Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.52

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9

GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
GO:0071977 Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium.
GO:1900377 Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process.
GO:1900232 Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
290	532	Pfam	PF00082	Subtilase family
290	532	InterPro	IPR000209	Peptidase S8/S53 domain
1	22	SignalP_EUK	SignalP-noTM	SignalP-noTM
177	521	PANTHER	PTHR43399	SUBTILISIN-RELATED
1	5	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	21	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
17	21	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	21	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
227	553	ProSiteProfiles	PS51892	Serine proteases, subtilase domain profile.
256	531	CDD	cd00306	Peptidases_S8_S53
295	308	PRINTS	PR00723	Subtilisin serine protease family (S8) signature
295	308	InterPro	IPR015500	Peptidase S8, subtilisin-related
253	272	PRINTS	PR00723	Subtilisin serine protease family (S8) signature
253	272	InterPro	IPR015500	Peptidase S8, subtilisin-related
496	512	PRINTS	PR00723	Subtilisin serine protease family (S8) signature
496	512	InterPro	IPR015500	Peptidase S8, subtilisin-related
22	590	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6	16	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
200	579	Gene3D	G3DSA:3.40.50.200	Peptidase S8/S53 domain
200	579	InterPro	IPR036852	Peptidase S8/S53 domain superfamily
497	507	ProSitePatterns	PS00138	Serine proteases, subtilase family, serine active site.
497	507	InterPro	IPR023828	Peptidase S8, subtilisin, Ser-active site
1	21	Phobius	SIGNAL_PEPTIDE	Signal peptide region
242	539	SUPERFAMILY	SSF52743	Subtilisin-like
242	539	InterPro	IPR036852	Peptidase S8/S53 domain superfamily
202	227	MobiDBLite	mobidb-lite	consensus disorder prediction
1	590	PIRSF	PIRSF029389	Subtilisin_rel_PA1242
1	590	InterPro	IPR016916	Uncharacterised conserved protein UCP029389, subtilisin-related

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1242	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.52

PA1242