Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1247
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: aprE PA1247
Status: annotated
Amino acids: 432
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306 The controlled release of proteins from a cell. GO:0046903 The controlled release of a substance by a cell or a tissue. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.844

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0009306 The controlled release of proteins from a cell.
GO:0046903 The controlled release of a substance by a cell or a tissue.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
86	170	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin
12	431	NCBIfam	TIGR01843	HlyD family type I secretion periplasmic adaptor subunit
12	431	InterPro	IPR010129	Type I secretion membrane fusion protein, HlyD family
54	111	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
92	112	Coils	Coil	Coil
149	176	Coils	Coil	Coil
208	228	Coils	Coil	Coil
54	85	Gene3D	G3DSA:2.40.50.100	-
304	414	Gene3D	G3DSA:2.40.30.170	-
1	11	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
34	432	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12	33	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
23	388	Pfam	PF00529	Cation efflux system protein CusB domain 1
23	388	InterPro	IPR043602	Cation efflux system protein CusB, domain 1
10	426	PANTHER	PTHR30386	MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
396	418	ProSitePatterns	PS00543	HlyD family secretion proteins signature.
396	418	InterPro	IPR006144	Secretion protein HlyD, conserved site
12	34	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
296	317	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
353	376	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
63	83	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
329	353	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
21	44	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
396	411	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
411	431	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1247	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.844
2				0.265

PA1247