Protein profile

PA1251

chemotaxis transducer

Genome: NC_002516.2

Gene: PA1251 Structure source: AlphaFold UniProt Q9I493
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Amino acids 541
Annotations 5
Features 41
PDB binders 0
Druggability 0.776

Overview

Basic information about this protein and its source genome.

Accession
PA1251
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1251
Status
annotated
Amino acids
541
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.776
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
31 190 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
324 507 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
324 507 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
188 210 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
81 101 Coils Coil Coil
269 505 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
269 505 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
16 41 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
16 41 InterPro IPR004090 Chemotaxis methyl-accepting receptor
377 404 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
377 404 InterPro IPR004090 Chemotaxis methyl-accepting receptor
188 208 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
188 208 InterPro IPR004090 Chemotaxis methyl-accepting receptor
406 435 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
406 435 InterPro IPR004090 Chemotaxis methyl-accepting receptor
279 540 SMART SM00283 MA_2
279 540 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
191 210 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
27 539 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
217 259 CDD cd06225 HAMP
306 497 CDD cd11386 MCP_signal
293 541 Gene3D G3DSA:1.10.287.950 -
209 261 Pfam PF00672 HAMP domain
209 261 InterPro IPR003660 HAMP domain
8 185 Pfam PF12729 Four helix bundle sensory module for signal transduction
8 185 InterPro IPR024478 Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain
211 541 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
212 264 ProSiteProfiles PS50885 HAMP domain profile.
212 264 InterPro IPR003660 HAMP domain
442 462 Coils Coil Coil
232 540 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
44 172 CDD cd19411 MCP2201-like_sensor
44 172 InterPro IPR047347 Putative sensory transducer protein YvaQ-like, ligand-binding sensor domain
212 541 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
212 264 SMART SM00304 HAMP_11
267 317 SMART SM00304 HAMP_11
267 317 InterPro IPR003660 HAMP domain
172 268 Gene3D G3DSA:6.10.340.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1251
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.776
2 0.329
5 0.248