Protein profile

PA1259

hypothetical protein

Genome: NC_002516.2

Gene: PA1259 lhpI Structure source: AlphaFold UniProt Q9I485

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Amino acids 580

Annotations 3

Features 17

PDB binders 0

Druggability 0.907

Overview

Basic information about this protein and its source genome.

Accession: PA1259
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1259 lhpI
Status: annotated
Amino acids: 580
Structure source: AlphaFold

4.2.1.171

GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0019470 The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.907

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

4.2.1.171

Gene Ontology (GO)

GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0019470 The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
161	561	Pfam	PF04412	Aconitase X
161	561	InterPro	IPR007506	Aconitase X catalytic domain, putative
7	114	SUPERFAMILY	SSF52016	LeuD/IlvD-like
166	563	CDD	cd01355	AcnX
166	563	InterPro	IPR007506	Aconitase X catalytic domain, putative
28	103	Pfam	PF01989	Aconitase X swivel domain
28	103	InterPro	IPR002840	Aconitase X swivel domain, putative
160	572	PANTHER	PTHR36577	DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)
439	535	SUPERFAMILY	SSF53732	Aconitase iron-sulfur domain
439	535	InterPro	IPR036008	Aconitase, iron-sulfur domain
12	117	CDD	cd01356	AcnX_swivel
12	117	InterPro	IPR002840	Aconitase X swivel domain, putative
7	140	Gene3D	G3DSA:3.50.30.10	Phosphohistidine domain
435	542	Gene3D	G3DSA:3.30.499.10	Aconitase, domain 3
435	542	InterPro	IPR015931	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
3	580	PIRSF	PIRSF036630	Aconts_X_fused
3	580	InterPro	IPR012047	Aconitase X

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1259	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.378
2				0.256