Protein profile

PA1260

amino acid ABC transporter substrate-binding protein

Genome: NC_002516.2

Gene: PA1260 Structure source: AlphaFold UniProt Q9I484
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Amino acids 273
Annotations 3
Features 17
PDB binders 3
Druggability 0.501

Overview

Basic information about this protein and its source genome.

Accession
PA1260
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1260
Status
annotated
Amino acids
273
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents. GO:0034589 The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.501
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents.
  • GO:0034589 The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
8 261 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
18 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 25 SignalP_EUK SignalP-noTM SignalP-noTM
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 17 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
7 264 PANTHER PTHR35936 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F
123 220 Gene3D G3DSA:3.40.190.10 -
37 260 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3
37 260 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
28 259 CDD cd13696 PBP2_Atu4678_like
33 257 Gene3D G3DSA:3.40.190.10 -
36 262 SMART SM00062 AABind_6
36 262 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
26 273 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1260
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.501

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
KH2
5KKW
Q4FLR5 221.3 Da LogP 0.55 TPSA 57.2 ✓ Ro5 ✓ Clean C[N+]1(CCCCC1)CCCS(=O)(=O)[O-]
ORN
3VVD
Q72JG5 132.2 Da LogP -0.86 TPSA 89.3 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CN
SLZ
3VV5
Q72JG5 164.2 Da LogP -0.91 TPSA 89.3 ✓ Ro5 ✓ Clean C(CSC[C@@H](C(=O)O)N)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.