Protein profile

PA1263

hypothetical protein

Genome: NC_002516.2

Gene: PA1263 Structure source: AlphaFold UniProt Q9I481
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Amino acids 314
Annotations 1
Features 21
PDB binders 0
Druggability 0.734

Overview

Basic information about this protein and its source genome.

Accession
PA1263
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1263
Status
annotated
Amino acids
314
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.734
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MRFWLTRYQFLLILVLALPVCPSEDFAMPLDAPASHAAESPAQPSRAEQLGAFLRRRRESIEPQRVGISRLGRRRTPGLRREEVAQLAGVGVTWYTWLEQGRAVRASEQVIGAIARALLCNETETHHLFNLAGLAAPTSARRAVCEKPSAATQAILDALDPLPAMVQNARFDIRGYNRAYCRLVGIDLAEIPEEDRNCIYLALTHERWRYCMANREEALPRMVGFFRAAMVERMGDPLWERQLQRCLEASAEFREIWRRNEVMGIENQLKRFRHARCGEFELQQTNWWSAPKNGDRLLVFVPLDDHARDCLEQL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
38 314 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
148 314 Gene3D G3DSA:3.30.450.180 -
22 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
49 128 Pfam PF13560 Helix-turn-helix domain
73 124 CDD cd00093 HTH_XRE
73 124 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
150 314 Pfam PF17765 MmyB-like transcription regulator ligand binding domain
150 314 InterPro IPR041413 MmyB-like transcription regulator ligand binding
10 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 17 SignalP_EUK SignalP-noTM SignalP-noTM
1 27 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
41 123 Gene3D G3DSA:1.10.260.40 -
41 123 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
43 314 PANTHER PTHR35010 BLL4672 PROTEIN-RELATED
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 27 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
53 125 SMART SM00530 mbf_short4
53 125 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
73 121 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
73 121 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1263
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.734
6 0.259