Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1266
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1266
Status: annotated
Amino acids: 417
Structure source: AlphaFold

GO

GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0019470 The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.812

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0019470 The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
1	22	Phobius	SIGNAL_PEPTIDE	Signal peptide region
6	28	PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature
271	289	PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature
100	108	PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature
139	163	PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature
196	310	Gene3D	G3DSA:3.50.50.60	-
196	310	InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
1	304	SUPERFAMILY	SSF51905	FAD/NAD(P)-binding domain
1	304	InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
2	137	Gene3D	G3DSA:3.50.50.60	-
2	137	InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
5	288	Pfam	PF07992	Pyridine nucleotide-disulphide oxidoreductase
5	288	InterPro	IPR023753	FAD/NAD(P)-binding domain
23	417	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
143	161	PRINTS	PR00368	FAD-dependent pyridine nucleotide reductase signature
7	26	PRINTS	PR00368	FAD-dependent pyridine nucleotide reductase signature
99	117	PRINTS	PR00368	FAD-dependent pyridine nucleotide reductase signature
261	283	PRINTS	PR00368	FAD-dependent pyridine nucleotide reductase signature
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	394	PANTHER	PTHR42949	ANAEROBIC GLYCEROL-3-PHOSPHATE DEHYDROGENASE SUBUNIT B
18	22	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
331	391	Gene3D	G3DSA:1.10.10.1100	-
331	391	InterPro	IPR041854	BFD-like [2Fe-2S]-binding domain superfamily
7	17	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	416	PIRSF	PIRSF037495	OoxA/HcnB
1	416	InterPro	IPR017224	Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1266	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.812

PA1266