Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1272
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cobO PA1272
Status: annotated
Amino acids: 203
Structure source: AlphaFold

EC

2.5.1.17

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817 Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.797

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

2.5.1.17

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0008817 Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin.
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
GO:0006779 The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
12	32	Coils	Coil	Coil
11	203	Gene3D	G3DSA:3.40.50.300	-
11	203	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
33	203	CDD	cd00561	CobA_ACA
33	203	InterPro	IPR003724	ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR
1	26	Pfam	PF12557	Cob(I)alamin adenosyltransferase N terminal
1	26	InterPro	IPR025826	Cob(I)alamin adenosyltransferase N-terminal domain
29	203	NCBIfam	TIGR00708	cob(I)yrinic acid a,c-diamide adenosyltransferase
29	203	InterPro	IPR003724	ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR
12	203	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
12	203	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
5	203	PANTHER	PTHR46638	CORRINOID ADENOSYLTRANSFERASE
5	203	InterPro	IPR003724	ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR
33	203	Pfam	PF02572	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP
6	203	PIRSF	PIRSF015617	Adenosyltransferase_CobA
6	203	InterPro	IPR003724	ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1272	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.797
1				0.37

PA1272