Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1277
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cobQ PA1277
Status: annotated
Amino acids: 490
Structure source: AlphaFold

GO

GO:0015420 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.538

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0015420 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
3	244	Gene3D	G3DSA:3.40.50.300	-
3	244	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
1	488	Hamap	MF_00028	Cobyric acid synthase [cobQ].
1	488	InterPro	IPR004459	Cobyric acid synthase CobQ
6	486	PANTHER	PTHR21343	DETHIOBIOTIN SYNTHETASE
8	478	NCBIfam	TIGR00313	cobyric acid synthase CobQ
8	478	InterPro	IPR004459	Cobyric acid synthase CobQ
254	437	Pfam	PF07685	CobB/CobQ-like glutamine amidotransferase domain
254	437	InterPro	IPR011698	CobB/CobQ-like glutamine amidotransferase
6	228	CDD	cd05389	CobQ_N
6	228	InterPro	IPR047045	Cobyric acid synthase, N-terminal domain
6	240	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
6	240	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
257	401	Gene3D	G3DSA:3.40.50.880	-
257	401	InterPro	IPR029062	Class I glutamine amidotransferase-like
252	439	ProSiteProfiles	PS51274	CobBQ-type GATase domain profile.
254	447	SUPERFAMILY	SSF52317	Class I glutamine amidotransferase-like
254	447	InterPro	IPR029062	Class I glutamine amidotransferase-like
255	444	CDD	cd01750	GATase1_CobQ
255	444	InterPro	IPR033949	Cobyric acid synthase, glutamine amidotransferase type 1
8	233	Pfam	PF01656	CobQ/CobB/MinD/ParA nucleotide binding domain
8	233	InterPro	IPR002586	CobQ/CobB/MinD/ParA nucleotide binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1277	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.314

PA1277