Protein profile

PA1278

bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase

Genome: NC_002516.2

Gene: PA1278 cobP Structure source: AlphaFold UniProt Q9I466
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Amino acids 173
Annotations 8
Features 13
PDB binders 2
Druggability 0.868

Overview

Basic information about this protein and its source genome.

Accession
PA1278
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1278 cobP
Status
annotated
Amino acids
173
Structure source
AlphaFold
EC
2.7.1.156 2.7.7.62
GO
GO:0043752 Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008820 Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate. GO:0005525 Binding to GTP, guanosine triphosphate. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.868
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 6 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

6
  • GO:0043752 Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP).
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0008820 Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate.
  • GO:0005525 Binding to GTP, guanosine triphosphate.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
4 169 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
4 169 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 169 FunFam G3DSA:3.40.50.300:FF:001825 Bifunctional adenosylcobalamin biosynthesis protein
4 168 Pfam PF02283 Cobinamide kinase / cobinamide phosphate guanyltransferase
4 168 InterPro IPR003203 Bifunctional adenosylcobalamin biosynthesis protein CobU/CobP
3 169 Gene3D G3DSA:3.40.50.300 -
3 169 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 171 PIRSF PIRSF006135 CobU
1 171 InterPro IPR003203 Bifunctional adenosylcobalamin biosynthesis protein CobU/CobP
4 166 CDD cd00544 CobU
4 166 InterPro IPR003203 Bifunctional adenosylcobalamin biosynthesis protein CobU/CobP
1 169 PANTHER PTHR34848 -
1 169 InterPro IPR003203 Bifunctional adenosylcobalamin biosynthesis protein CobU/CobP

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1278
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.868

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
5GP
1C9K
Q05599 363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
POP
1C9K
Q05599 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.