Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1285
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1285
Status: annotated
Amino acids: 149
Structure source: AlphaFold

GO

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.977

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
16	147	PANTHER	PTHR33164	TRANSCRIPTIONAL REGULATOR, MARR FAMILY
16	147	InterPro	IPR039422	Transcription regulators MarR/SlyA-like
14	148	Gene3D	G3DSA:1.10.10.10	-
14	148	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
16	147	ProSiteProfiles	PS50995	MarR-type HTH domain profile.
16	147	InterPro	IPR000835	MarR-type HTH domain
36	135	SMART	SM00347	marrlong4
36	135	InterPro	IPR000835	MarR-type HTH domain
13	146	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
13	146	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
95	111	PRINTS	PR00598	Bacterial regulatory protein MarR family signature
95	111	InterPro	IPR000835	MarR-type HTH domain
125	145	PRINTS	PR00598	Bacterial regulatory protein MarR family signature
125	145	InterPro	IPR000835	MarR-type HTH domain
60	76	PRINTS	PR00598	Bacterial regulatory protein MarR family signature
60	76	InterPro	IPR000835	MarR-type HTH domain
42	98	Pfam	PF12802	MarR family
42	98	InterPro	IPR000835	MarR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1285	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.977
1				0.821
3				0.817

PA1285