Amino acids
399
Annotations
3
Features
49
PDB binders
4
Druggability
0.91
Overview
Basic information about this protein and its source genome.
- Accession
- PA1286
- Gene
- PA1286
- Status
- annotated
- Amino acids
- 399
- Structure source
- AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 27.805
- Human E-value
- 3.89e-08
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- CytoplasmicMembrane
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.91
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
3 GO
Gene Ontology (GO)
3- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
- GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
- GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
Sequence Features
Domain/signature hits from InterPro and related databases.
49 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 237 | 241 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 74 | 92 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 5 | 384 | CDD | cd17355 | MFS_YcxA_like |
| 134 | 159 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 19 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 14 | 312 | Pfam | PF07690 | Major Facilitator Superfamily |
| 14 | 312 | InterPro | IPR011701 | Major facilitator superfamily |
| 296 | 300 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 275 | 295 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 161 | 183 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 93 | 97 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 160 | 164 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 2 | 383 | Gene3D | G3DSA:1.20.1250.20 | MFS general substrate transporter like domains |
| 2 | 383 | InterPro | IPR036259 | MFS transporter superfamily |
| 1 | 3 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 327 | 332 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 98 | 122 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 209 | 231 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 63 | 73 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 264 | 274 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 5 | 389 | ProSiteProfiles | PS50850 | Major facilitator superfamily (MFS) profile. |
| 5 | 389 | InterPro | IPR020846 | Major facilitator superfamily domain |
| 165 | 183 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 354 | 364 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 306 | 328 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 135 | 157 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 365 | 384 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 333 | 355 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 6 | 369 | PANTHER | PTHR11360 | MONOCARBOXYLATE TRANSPORTER |
| 43 | 62 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 280 | 302 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 101 | 123 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 385 | 399 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 37 | 56 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 184 | 209 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 210 | 236 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 333 | 353 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 301 | 326 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 5 | 27 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 16 | 19 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 246 | 268 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 69 | 91 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 123 | 133 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 20 | 42 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 365 | 384 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 3 | 388 | SUPERFAMILY | SSF103473 | MFS general substrate transporter |
| 3 | 388 | InterPro | IPR036259 | MFS transporter superfamily |
| 242 | 263 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 4 | 15 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA1286
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.91 | ||||||
| 1 | 0.888 | ||||||
| 10 | 0.816 | ||||||
| 2 | 0.506 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
58 records
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| 02Q | A0LNN5 | 164.2 Da LogP 2.01 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
Cc1ccccc1CCC(=O)O
|
|
| 1HN | A0LNN5 | 188.2 Da LogP 2.24 TPSA 57.5 | ✓ Ro5 | ✓ Clean |
c1ccc2c(c1)ccc(c2O)C(=O)O
|
|
| FIV | A0LNN5 | 172.2 Da LogP 2.54 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
c1ccc2cc(ccc2c1)C(=O)O
|
|
| HCI | A0LNN5 | 150.2 Da LogP 1.70 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
c1ccc(cc1)CCC(=O)O
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
| Ligand | UniProt (homolog) | pchembl | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| CHEMBL3335793 | O60669 | 7.70 | 515.5 Da LogP 2.12 TPSA 122.5 | 1 viol. | ✓ Clean |
Cc1[nH]nc(C(F)(F)F)c1Cc1sc2c(c1C(=O)N1C[C@](C)(…
|
| CHEMBL4802043 | P57787 | 6.60 | 538.0 Da LogP 4.59 TPSA 127.7 | 1 viol. | ✓ Clean |
CCOc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C#Cc2cnc(C(=O)O)…
|
| CHEMBL5723356 | O60669 | 6.60 | 529.1 Da LogP 3.19 TPSA 97.4 | 1 viol. | ✓ Clean |
CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N3CC[C@@H](O)C3)…
|
| CHEMBL5282978 | P57787 | 6.52 | 1461.7 Da LogP 7.58 TPSA 401.8 | 4 viol. | ✓ Clean |
CC1(CCCCCC(=O)NCCOCCOCCOCCOc2ccnc3c(S(=O)(=O)Nc…
|
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC14977605 | 0.985 | 492.6 Da LogP 2.76 TPSA 97.4 | ✓ Ro5 | ✓ Clean |
CC(C)Cn1c(=O)n(C)c(=O)c2c(C(=O)N3CC[C@@H](O)C3)…
|
| ZINC164010 | 0.870 | 222.2 Da LogP 3.69 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2cc3ccccc3cc2c1
|
| ZINC156288 | 0.810 | 216.2 Da LogP 2.24 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2cc(C(=O)O)ccc2c1
|
| ZINC406914 | 0.800 | 222.2 Da LogP 1.72 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1ccc(CCC(=O)O)cc1
|
| ZINC2528279 | 0.773 | 216.2 Da LogP 2.24 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccc(C(=O)O)cc2c1
|
| ZINC406170 | 0.767 | 292.3 Da LogP 3.47 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccccc1C(=O)c1ccc2ccccc2c1O
|
| ZINC9998612 | 0.750 | 226.3 Da LogP 3.37 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1ccc(-c2ccccc2)cc1
|
| ZINC2163727 | 0.739 | 222.2 Da LogP 1.72 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1cccc(CCC(=O)O)c1
|
| ZINC2599161 | 0.739 | 266.3 Da LogP 3.39 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2cc3cc(C(=O)O)ccc3cc2c1
|
| ZINC1673354 | 0.727 | 238.3 Da LogP 3.82 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
O=C(CCc1ccccc1)CCc1ccccc1
|
| ZINC1693912 | 0.727 | 266.3 Da LogP 3.39 TPSA 34.1 | ✓ Ro5 | Alert |
O=C(CCc1ccccc1)C(=O)CCc1ccccc1
|
| ZINC3844983 | 0.720 | 260.3 Da LogP 3.91 TPSA 34.1 | ✓ Ro5 | Alert |
O=C(C(=O)c1ccc2ccccc2c1)c1ccccc1
|
| ZINC2529014 | 0.704 | 248.3 Da LogP 4.21 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc(-c2ccc3ccccc3c2)cc1
|
| ZINC39428991 | 0.704 | 222.2 Da LogP 3.69 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2c(ccc3ccccc32)c1
|
| ZINC44672411 | 0.704 | 248.3 Da LogP 4.21 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2cc(-c3ccccc3)ccc2c1
|
| ZINC2516358 | 0.700 | 224.3 Da LogP 3.81 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
Cc1ccccc1CCC(=O)c1ccccc1
|
| ZINC143280795 | 0.694 | 430.4 Da LogP 2.68 TPSA 110.0 | ✓ Ro5 | ✓ Clean |
Cc1[nH]nc(C(F)(F)F)c1Cc1sc2c(c1C(=O)O)c(=O)n(C)…
|
| ZINC1680758 | 0.692 | 232.3 Da LogP 4.07 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
O=C(c1ccccc1)c1ccc2ccccc2c1
|
| ZINC247409588 | 0.692 | 220.3 Da LogP 2.44 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCC(=O)CCc1ccccc1
|
| ZINC29563531 | 0.692 | 200.2 Da LogP 2.11 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
O=C(O)C(=O)c1ccc2ccccc2c1
|
| ZINC1558609 | 0.680 | 248.4 Da LogP 4.43 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCc1ccccc1
|
| ZINC2510086 | 0.680 | 262.4 Da LogP 4.82 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCCCc1ccccc1
|
| ZINC2575483 | 0.680 | 206.3 Da LogP 3.26 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCc1ccccc1
|
| ZINC2575484 | 0.680 | 220.3 Da LogP 3.65 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCc1ccccc1
|
| ZINC2575485 | 0.680 | 234.3 Da LogP 4.04 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCCc1ccccc1
|
| ZINC71256874 | 0.679 | 248.3 Da LogP 4.21 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccc(-c3ccccc3)cc2c1
|
| ZINC84551502 | 0.677 | 243.1 Da LogP 2.77 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
Cc1cccc(CCC(=O)O)c1Br
|
| ZINC11962728 | 0.667 | 242.3 Da LogP 3.50 TPSA 46.5 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1ccc(Oc2ccccc2)cc1
|
| ZINC1727327 | 0.667 | 208.2 Da LogP 1.33 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1ccccc1CC(=O)O
|
| ZINC19436641 | 0.667 | 203.2 Da LogP 1.66 TPSA 69.6 | ✓ Ro5 | ✓ Clean |
O=C(NO)c1ccc2ccccc2c1O
|
| ZINC345518 | 0.667 | 222.2 Da LogP 3.69 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccc3ccccc3c2c1
|
| ZINC49820418 | 0.667 | 226.3 Da LogP 3.37 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1cccc(-c2ccccc2)c1
|
| ZINC100476725 | 0.656 | 290.3 Da LogP 4.00 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
O=C(CC(=O)c1ccc2ccccc2c1O)c1ccccc1
|
| ZINC71392 | 0.656 | 263.3 Da LogP 3.80 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
O=C(Nc1ccccc1)c1ccc2ccccc2c1O
|
| ZINC1512447 | 0.655 | 276.3 Da LogP 3.77 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccccc1C(=O)c1ccc2ccccc2c1
|
| ZINC156804 | 0.655 | 251.1 Da LogP 3.30 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1Br
|
| ZINC1571200 | 0.655 | 216.2 Da LogP 2.24 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
O=C(O)c1ccc2ccccc2c1C(=O)O
|
| ZINC163985 | 0.655 | 256.3 Da LogP 3.28 TPSA 46.5 | ✓ Ro5 | ✓ Clean |
O=C(O)CCc1ccc(OCc2ccccc2)cc1
|
| ZINC2529015 | 0.655 | 248.3 Da LogP 4.21 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
O=C(O)c1cccc(-c2ccc3ccccc3c2)c1
|
| ZINC144318170 | 0.654 | 214.2 Da LogP 2.74 TPSA 54.4 | ✓ Ro5 | ✓ Clean |
CC(=O)c1ccc2cc(C(=O)O)ccc2c1
|
| ZINC6535079 | 0.654 | 204.2 Da LogP 1.95 TPSA 77.8 | ✓ Ro5 | Alert |
O=C(O)c1ccc2cc(O)c(O)cc2c1
|
| ZINC1667321 | 0.645 | 200.2 Da LogP 3.14 TPSA 37.3 | ✓ Ro5 | ✓ Clean |
CCC(=O)c1ccc2ccccc2c1O
|
| ZINC19837284 | 0.645 | 201.2 Da LogP 1.90 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
CNC(=O)c1ccc2ccccc2c1O
|
| ZINC2516359 | 0.645 | 238.3 Da LogP 4.12 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
Cc1ccccc1CCC(=O)c1ccccc1C
|
| ZINC2516382 | 0.645 | 252.4 Da LogP 4.43 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
Cc1ccccc1CCC(=O)c1c(C)cccc1C
|
| ZINC2378594 | 0.643 | 224.2 Da LogP 3.58 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
O=C(c1ccc2ccccc2c1)C(F)(F)F
|
| ZINC3132463 | 0.643 | 212.3 Da LogP 4.07 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
CC(C)(C)C(=O)c1ccc2ccccc2c1
|
| ZINC394670686 | 0.643 | 273.5 Da LogP 4.39 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
O=C(c1ccc2ccccc2c1)C(Cl)(Cl)Cl
|
| ZINC1089845 | 0.640 | 210.3 Da LogP 3.50 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
O=C(CCc1ccccc1)c1ccccc1
|
| ZINC15780483 | 0.640 | 224.3 Da LogP 3.43 TPSA 17.1 | ✓ Ro5 | ✓ Clean |
O=C(CCc1ccccc1)Cc1ccccc1
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.