Protein profile

PA1287

glutathione peroxidase

Genome: NC_002516.2

Gene: PA1287 Structure source: AlphaFold UniProt Q9I457
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Amino acids 184
Annotations 4
Features 31
PDB binders 3
Druggability 0.414

Overview

Basic information about this protein and its source genome.

Accession
PA1287
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1287
Status
annotated
Amino acids
184
Structure source
AlphaFold
GO
GO:0004601 Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O. GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004602 Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
43.103
Human E-value
1.24e-06
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.414
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0004601 Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O.
  • GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
  • GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
  • GO:0004602 Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
34 180 SUPERFAMILY SSF52833 Thioredoxin-like
34 180 InterPro IPR036249 Thioredoxin-like superfamily
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
18 183 FunFam G3DSA:3.40.30.10:FF:000246 Glutathione peroxidase
1 184 PIRSF PIRSF000303 Glutathion_perox
1 184 InterPro IPR000889 Glutathione peroxidase
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 184 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 183 Gene3D G3DSA:3.40.30.10 Glutaredoxin
11 181 ProSiteProfiles PS51352 Thioredoxin domain profile.
11 181 InterPro IPR013766 Thioredoxin domain
16 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
142 151 PRINTS PR01011 Glutathione peroxidase family signature
142 151 InterPro IPR000889 Glutathione peroxidase
47 64 PRINTS PR01011 Glutathione peroxidase family signature
47 64 InterPro IPR000889 Glutathione peroxidase
82 98 PRINTS PR01011 Glutathione peroxidase family signature
82 98 InterPro IPR000889 Glutathione peroxidase
40 179 PANTHER PTHR11592 GLUTATHIONE PEROXIDASE
40 179 InterPro IPR000889 Glutathione peroxidase
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
17 184 ProSiteProfiles PS51355 Glutathione peroxidase profile.
17 184 InterPro IPR000889 Glutathione peroxidase
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
39 134 Pfam PF00255 Glutathione peroxidase
39 134 InterPro IPR000889 Glutathione peroxidase
49 64 ProSitePatterns PS00460 Glutathione peroxidases active site.
49 64 InterPro IPR029759 Glutathione peroxidase active site
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
37 180 CDD cd00340 GSH_Peroxidase
37 180 InterPro IPR000889 Glutathione peroxidase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1287
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.414
1 0.211

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

106 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
G9N
6HKQ
P36969 477.4 Da LogP 5.08 TPSA 58.6 1 viol. ✓ Clean COc1ccc(cc1Cl)N([C@H](c2cccs2)C(=O)NCCc3ccccc3)…
NH4
3E0U
Q8T8E2 18.0 Da LogP 0.38 TPSA 36.5 ✓ Ro5 ✓ Clean [NH4+]
POP
2WGR
Q00277 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.