Protein profile

PA1291

hypothetical protein

Genome: NC_002516.2

Gene: PA1291 Structure source: AlphaFold UniProt Q9I453
Export view
Amino acids 279
Annotations 2
Features 15
PDB binders 0
Druggability 0.945

Overview

Basic information about this protein and its source genome.

Accession
PA1291
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1291
Status
annotated
Amino acids
279
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016298 Catalysis of the hydrolysis of a lipid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0016298 Catalysis of the hydrolysis of a lipid.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
144 161 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 275 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
5 275 InterPro IPR029058 Alpha/Beta hydrolase fold
41 263 Pfam PF12697 Alpha/beta hydrolase family
41 263 InterPro IPR000073 Alpha/beta hydrolase fold-1
112 132 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 274 FunFam G3DSA:3.40.50.1820:FF:000599 Chromosome 23, whole genome shotgun sequence
133 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
162 279 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 274 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
1 274 InterPro IPR029058 Alpha/Beta hydrolase fold
144 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 279 PIRSF PIRSF037442 UCP037442_abhydr
1 279 InterPro IPR017208 Uncharacterised conserved protein UCP037442, alpha/beta hydrolase, RSp0795
1 111 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1291
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.945