Protein profile

PA1296

2-hydroxyacid dehydrogenase

Genome: NC_002516.2

Gene: PA1296 Structure source: AlphaFold UniProt Q9I448
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Amino acids 310
Annotations 4
Features 8
PDB binders 5
Druggability 0.659

Overview

Basic information about this protein and its source genome.

Accession
PA1296
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1296
Status
annotated
Amino acids
310
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0030267 Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. GO:0016618 Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0051287 Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.338
Human E-value
2.58e-15
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.659
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MRLLILERDHALYAALLMAADPSLKVVAGDDPLQLIDAASECSIWLGQPDLVAQMLRQGVHPVWVQSTWAGITPLLAADLPKDYSLTRAVGIFGQVMSEYLLTYMLAHERQFLGRLASQVGSQWDSRTPGGLRGRQVVIVGTGEIGQAVAHTLSGFGMDLTGVAKNPRSLVPFNRMGSLDDLGRLVETADYLINLLPDTPDTHDIYDRALFARLKPTALFINAGRGVAVVDADLVAALENNQLAGAVIDVCREEPLPANHLFWHTPRLLLTGHTAAPTLPGAMVELFRDNLARFWAGTAMRGEVDFARGY

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0030267 Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.
  • GO:0016618 Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+.
  • GO:0051287 Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
97 275 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
97 275 InterPro IPR036291 NAD(P)-binding domain superfamily
1 310 CDD cd05300 2-Hacid_dh_1
94 278 Gene3D G3DSA:3.40.50.720 -
103 275 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
103 275 InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
48 310 PANTHER PTHR43333 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN
21 300 Gene3D G3DSA:3.40.50.720 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1296
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.659
1 0.649
3 0.603

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
7N5
5MH5
Q2VEQ7 130.1 Da LogP 0.83 TPSA 54.4 ✓ Ro5 ✓ Clean CCCCC(=O)C(=O)O
GLV
6OXN
P75913 74.0 Da LogP -0.73 TPSA 54.4 ✓ Ro5 ✓ Clean C(=O)C(=O)O
OXD
5TSD
Q2KDT2 90.0 Da LogP -0.84 TPSA 74.6 ✓ Ro5 ✓ Clean C(=O)(C(=O)O)O
PE4
4N18
B5XVG7 354.4 Da LogP 0.11 TPSA 84.8 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCOCCO
TLA
5BQF
Q2KDT2 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.