Protein profile

PA1321

protoheme IX farnesyltransferase

Genome: NC_002516.2

Gene: cyoE Structure source: ColabFold
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Amino acids 296
Annotations 4
Features 38
PDB binders 0
Druggability 0.785

Overview

Basic information about this protein and its source genome.

Accession
PA1321
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
cyoE
Status
annotated
Amino acids
296
Structure source
ColabFold
GO
GO:0008495 Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.842
Human E-value
4.16e-19
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.785
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008495 Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.
  • GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
  • GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records
Show feature table
Start End DB Term Name
229 233 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
108 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
81 103 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 278 CDD cd13957 PT_UbiA_Cox10
7 278 InterPro IPR006369 Protohaem IX farnesyltransferase
161 183 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
81 102 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
209 228 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
233 255 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 164 FunFam G3DSA:1.10.357.140:FF:000001 Protoheme IX farnesyltransferase
287 296 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
253 263 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
234 252 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 107 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 28 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
207 229 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
36 60 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
264 286 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 35 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
61 80 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
264 286 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
108 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 282 NCBIfam TIGR01473 heme o synthase
4 282 InterPro IPR006369 Protohaem IX farnesyltransferase
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 284 Hamap MF_00154 Protoheme IX farnesyltransferase [cyoE].
2 284 InterPro IPR006369 Protohaem IX farnesyltransferase
38 60 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
57 79 ProSitePatterns PS00943 UbiA prenyltransferase family signature.
57 79 InterPro IPR030470 UbiA prenyltransferase conserved site
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
128 208 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 282 PANTHER PTHR43448 PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
13 168 Gene3D G3DSA:1.10.357.140 UbiA prenyltransferase
13 168 InterPro IPR044878 UbiA prenyltransferase superfamily
19 267 Pfam PF01040 UbiA prenyltransferase family
19 267 InterPro IPR000537 UbiA prenyltransferase family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA1321
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.785