Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1345
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1345
Status: annotated
Amino acids: 529
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion. GO:0004639 Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.637

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MSAASLATLDGSLRMTLVEQPRPPALADLGSRLMIVVERREDWASYLPSEEVLTAQEYLEQSARDHGGRRVQVINLCRGYKYLGLGYYCSLLAEARGHRVIPSLRCISELARKSVYGLALGGLDKALDKALCRTPYGATDGFTLTLYFGHTEFEPLADLARQLFEAFPCPILLVEFRRQQGWHIEGVRPGVLNRLRSDQEDVFADALDGFSRRAWRMPRSRRVARYDMAILHDPDEALPPSNPQALANFVRVGASLGIDVELIGRKDYARLAEFDALLIRETTRVDHHTYRFAEKAEREGLVVMDDPASILRCTNKVYLADLLGCRQLGMPLTEILYKERPQDWQRVARRLGFPLVLKIPDGCFSRGVVKVNDDSELLAAASELFERSVLLLAQEFFYTEYDWRIGVLDRQPLYACQYFMSRGHWQIYNHKADGQDVNGECRAVPLEQVPPAVLELALEAAGLIGDGLYGVDLKQAGDKVLVIEVNDNPNIDAGVEDGQLGDELYRRILQAFVQRLELKHRGQLSKALR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0046872 Binding to a metal ion.
GO:0004639 Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
266	493	PANTHER	PTHR21621	RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN
56	206	Pfam	PF14401	RimK-like ATPgrasp N-terminal domain
56	206	InterPro	IPR025839	RimK-like ATPgrasp N-terminal domain
306	514	SUPERFAMILY	SSF56059	Glutathione synthetase ATP-binding domain-like
322	513	ProSiteProfiles	PS50975	ATP-grasp fold profile.
322	513	InterPro	IPR011761	ATP-grasp fold
316	492	Pfam	PF08443	RimK-like ATP-grasp domain
316	492	InterPro	IPR013651	ATP-grasp fold, RimK-type
399	515	FunFam	G3DSA:3.30.470.20:FF:000052	Ribosomal protein S6 modification enzyme
335	397	Gene3D	G3DSA:3.30.1490.20	-
335	397	InterPro	IPR013815	ATP-grasp fold, subdomain 1
399	517	Gene3D	G3DSA:3.30.470.20	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1345	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.283
1				0.243

PA1345