Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1347
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1347
Status: annotated
Amino acids: 230
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.653

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
124	213	Gene3D	G3DSA:1.10.10.10	-
124	213	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
154	168	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
154	168	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
168	184	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
168	184	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
184	196	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
184	196	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
151	208	SMART	SM00421	luxrmega5
151	208	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
154	199	CDD	cd06170	LuxR_C_like
154	199	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
145	212	SUPERFAMILY	SSF46894	C-terminal effector domain of the bipartite response regulators
145	212	InterPro	IPR016032	Signal transduction response regulator, C-terminal effector
150	212	ProSiteProfiles	PS50043	LuxR-type HTH domain profile.
150	212	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
150	201	PANTHER	PTHR44688	-
154	198	Pfam	PF00196	Bacterial regulatory proteins, luxR family
154	198	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
28	130	Pfam	PF08448	PAS fold
28	130	InterPro	IPR013656	PAS fold-4

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1347	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.653

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
A1U	7DWM	A2I306	124.1 Da LogP 0.80 TPSA 46.0	✓ Ro5	✓ Clean	`Cc1cnc(c(n1)C)O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC34742056	0.520	234.0 Da LogP 1.70 TPSA 25.8	✓ Ro5	✓ Clean	`Cc1cnc(I)c(C)n1`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA1347