Protein profile

PA1352

hypothetical protein

Genome: NC_002516.2

Gene: PA1352 Structure source: AlphaFold UniProt Q9I3Z2
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Amino acids 403
Annotations 2
Features 49
PDB binders 0
Druggability 0.922

Overview

Basic information about this protein and its source genome.

Accession
PA1352
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1352
Status
annotated
Amino acids
403
Structure source
AlphaFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.922
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
41 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
164 186 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
125 135 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
370 387 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 390 PANTHER PTHR42910 TRANSPORTER SCO4007-RELATED
137 159 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
187 219 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
302 323 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 40 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 319 Pfam PF07690 Major Facilitator Superfamily
22 319 InterPro IPR011701 Major facilitator superfamily
343 365 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
167 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
78 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
242 246 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
247 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 25 SignalP_EUK SignalP-TM SignalP-TM
13 386 CDD cd17324 MFS_NepI_like
369 388 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
156 166 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
365 369 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
78 96 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
297 301 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
136 155 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
301 323 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 392 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
12 392 InterPro IPR020846 Major facilitator superfamily domain
267 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
97 101 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
280 297 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
220 241 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 389 SUPERFAMILY SSF103473 MFS general substrate transporter
9 389 InterPro IPR036259 MFS transporter superfamily
67 77 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
102 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
10 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
102 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
278 296 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
388 403 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
324 343 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
251 273 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
344 364 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 389 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
219 241 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1352
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.922
2 0.462