Protein profile

PA1368

hypothetical protein

Genome: NC_002516.2

Gene: PA1368 Structure source: AlphaFold UniProt Q9I3X6

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Amino acids 474

Annotations 3

Features 7

PDB binders 0

Druggability 0.48

Overview

Basic information about this protein and its source genome.

Accession: PA1368
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1368
Status: annotated
Amino acids: 474
Structure source: AlphaFold

GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.48

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records

Show feature table

Start	End	DB	Term	Name
56	121	Pfam	PF05598	Transposase domain (DUF772)
56	121	InterPro	IPR008490	Transposase InsH, N-terminal
1	473	PANTHER	PTHR33408	TRANSPOSASE
231	456	Pfam	PF01609	Transposase DDE domain
231	456	InterPro	IPR002559	Transposase IS4-like domain
9	461	NCBIfam	NF033551	IS1182 family transposase
9	461	InterPro	IPR047629	IS1182 transposase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1368	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.48
16				0.232