Protein profile

PA1374

hypothetical protein

Genome: NC_002516.2

Gene: PA1374 Structure source: Experimental + AlphaFold UniProt Q9I3X0
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Amino acids 168
Annotations 4
Features 9
PDB binders 0
Druggability 0.878

Overview

Basic information about this protein and its source genome.

Accession
PA1374
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1374
Status
annotated
Amino acids
168
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.878
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
11 108 ProSiteProfiles PS51118 HxlR-type HTH domain profile.
11 108 InterPro IPR002577 Helix-turn-helix, HxlR type
1 153 PANTHER PTHR33204 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
20 105 Pfam PF01638 HxlR-like helix-turn-helix
20 105 InterPro IPR002577 Helix-turn-helix, HxlR type
6 143 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 143 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 168 Gene3D G3DSA:1.10.10.10 -
1 168 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4GCV
X-ray 2.30 Å A,B,C,D,E,F,G,H,I,J,K,L
100.0% 1-168
PDBe RCSB PDBj File
Viewing
AlphaFold PA1374
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.82 0.035