Protein profile

PA1435

resistance-nodulation-cell division (RND) efflux membrane fusion protein

Genome: NC_002516.2

Gene: PA1435 Structure source: AlphaFold UniProt Q9I3R2
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Amino acids 385
Annotations 5
Features 19
PDB binders 0
Druggability 0.534

Overview

Basic information about this protein and its source genome.

Accession
PA1435
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1435
Status
annotated
Amino acids
385
Structure source
AlphaFold
GO
GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.534
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
  • GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
62 298 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
46 370 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
46 370 InterPro IPR006143 RND efflux pump, membrane fusion protein
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
105 178 FunFam G3DSA:1.10.287.470:FF:000044 Probable RND efflux membrane fusion protein
30 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
282 371 FunFam G3DSA:2.40.420.20:FF:000020 Probable RND efflux membrane fusion protein
38 385 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
70 291 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
70 291 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
11 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
282 371 Gene3D G3DSA:2.40.420.20 -
64 281 Gene3D G3DSA:2.40.30.170 -
111 138 Coils Coil Coil
9 374 PANTHER PTHR30469 MULTIDRUG RESISTANCE PROTEIN MDTA
105 178 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
70 214 Gene3D G3DSA:2.40.50.100 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1435
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.534
11 0.297