Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1443
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: fliM PA1443
Status: annotated
Amino acids: 323
Structure source: AlphaFold

GO

GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0050918 The directed movement of a motile cell or organism towards a higher concentration of a chemical. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
GO:0050918 The directed movement of a motile cell or organism towards a higher concentration of a chemical.
GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
114	133	PRINTS	PR00955	Flagellar motor switch protein FliM signature
114	133	InterPro	IPR001689	Flagellar motor switch protein FliM
4	17	PRINTS	PR00955	Flagellar motor switch protein FliM signature
4	17	InterPro	IPR001689	Flagellar motor switch protein FliM
89	105	PRINTS	PR00955	Flagellar motor switch protein FliM signature
89	105	InterPro	IPR001689	Flagellar motor switch protein FliM
211	229	PRINTS	PR00955	Flagellar motor switch protein FliM signature
211	229	InterPro	IPR001689	Flagellar motor switch protein FliM
247	322	SUPERFAMILY	SSF101801	Surface presentation of antigens (SPOA)
247	322	InterPro	IPR036429	SpoA-like superfamily
44	230	Gene3D	G3DSA:3.40.1550.10	-
44	230	InterPro	IPR028976	CheC-like superfamily
1	320	PANTHER	PTHR30034	FLAGELLAR MOTOR SWITCH PROTEIN FLIM
3	323	PIRSF	PIRSF002888	FliM
3	323	InterPro	IPR001689	Flagellar motor switch protein FliM
6	230	SUPERFAMILY	SSF103039	CheC-like
6	230	InterPro	IPR028976	CheC-like superfamily
241	323	Gene3D	G3DSA:2.30.330.10	-
241	323	InterPro	IPR036429	SpoA-like superfamily
251	319	Pfam	PF01052	Type III flagellar switch regulator (C-ring) FliN C-term
251	319	InterPro	IPR001543	Flagellar motor switch protein FliN-like, C-terminal domain
5	319	NCBIfam	TIGR01397	flagellar motor switch protein FliM
5	319	InterPro	IPR001689	Flagellar motor switch protein FliM
38	229	Pfam	PF02154	Flagellar motor switch protein FliM
38	229	InterPro	IPR001689	Flagellar motor switch protein FliM
48	227	CDD	cd17908	FliM
48	227	InterPro	IPR001689	Flagellar motor switch protein FliM
44	230	FunFam	G3DSA:3.40.1550.10:FF:000001	Flagellar motor switch protein FliM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1443	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.532
2				0.284

PA1443