Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1444
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: fliN PA1444
Status: annotated
Amino acids: 157
Structure source: AlphaFold

GO

GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). GO:0004721 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.239

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9

GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0003774 Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
GO:0004721 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:1902021 Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility.
GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
78	147	Pfam	PF01052	Type III flagellar switch regulator (C-ring) FliN C-term
78	147	InterPro	IPR001543	Flagellar motor switch protein FliN-like, C-terminal domain
1	66	MobiDBLite	mobidb-lite	consensus disorder prediction
66	157	FunFam	G3DSA:2.30.330.10:FF:000001	Flagellar motor switch protein FliN
37	157	PANTHER	PTHR43484	-
110	123	PRINTS	PR00956	Flagellar motor switch protein FliN signature
110	123	InterPro	IPR001172	Flagellar motor switch FliN/Type III secretion HrcQb
77	93	PRINTS	PR00956	Flagellar motor switch protein FliN signature
77	93	InterPro	IPR001172	Flagellar motor switch FliN/Type III secretion HrcQb
94	110	PRINTS	PR00956	Flagellar motor switch protein FliN signature
94	110	InterPro	IPR001172	Flagellar motor switch FliN/Type III secretion HrcQb
123	138	PRINTS	PR00956	Flagellar motor switch protein FliN signature
123	138	InterPro	IPR001172	Flagellar motor switch FliN/Type III secretion HrcQb
70	157	Gene3D	G3DSA:2.30.330.10	-
70	157	InterPro	IPR036429	SpoA-like superfamily
74	149	NCBIfam	TIGR02480	flagellar motor switch protein FliN
74	149	InterPro	IPR012826	Flagellar motor switch FliN
74	155	SUPERFAMILY	SSF101801	Surface presentation of antigens (SPOA)
74	155	InterPro	IPR036429	SpoA-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1444	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.239

PA1444