Protein profile

PA1446

flagellar biosynthesis protein FliP

Genome: NC_002516.2

Gene: PA1446 fliP Structure source: AlphaFold UniProt Q51468
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Amino acids 255
Annotations 6
Features 53
PDB binders 2
Druggability 0.924

Overview

Basic information about this protein and its source genome.

Accession
PA1446
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1446 fliP
Status
annotated
Amino acids
255
Structure source
AlphaFold
GO
GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
  • GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

53 records
Show feature table
Start End DB Term Name
50 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 26 SignalP_EUK SignalP-TM SignalP-TM
152 164 PRINTS PR00951 Flagellar biosynthetic protein FliP signature
152 164 InterPro IPR005837 Flagellar transport protein FliP
52 61 PRINTS PR00951 Flagellar biosynthetic protein FliP signature
52 61 InterPro IPR005837 Flagellar transport protein FliP
124 138 PRINTS PR00951 Flagellar biosynthetic protein FliP signature
124 138 InterPro IPR005837 Flagellar transport protein FliP
112 124 PRINTS PR00951 Flagellar biosynthetic protein FliP signature
112 124 InterPro IPR005837 Flagellar transport protein FliP
242 252 PRINTS PR00951 Flagellar biosynthetic protein FliP signature
242 252 InterPro IPR005837 Flagellar transport protein FliP
174 186 PRINTS PR00951 Flagellar biosynthetic protein FliP signature
174 186 InterPro IPR005837 Flagellar transport protein FliP
95 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
221 231 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
224 246 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
56 252 NCBIfam TIGR01103 flagellar type III secretion system pore protein FliP
56 252 InterPro IPR005837 Flagellar transport protein FliP
84 94 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
181 196 ProSitePatterns PS01060 Flagella transport protein fliP family signature 1.
181 196 InterPro IPR005838 Type III secretion system inner membrane P protein
253 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
226 251 PRINTS PR01302 Type III secretion system inner membrane P protein family signature
226 251 InterPro IPR005838 Type III secretion system inner membrane P protein
73 93 PRINTS PR01302 Type III secretion system inner membrane P protein family signature
73 93 InterPro IPR005838 Type III secretion system inner membrane P protein
93 112 PRINTS PR01302 Type III secretion system inner membrane P protein family signature
93 112 InterPro IPR005838 Type III secretion system inner membrane P protein
202 223 PRINTS PR01302 Type III secretion system inner membrane P protein family signature
202 223 InterPro IPR005838 Type III secretion system inner membrane P protein
54 73 PRINTS PR01302 Type III secretion system inner membrane P protein family signature
54 73 InterPro IPR005838 Type III secretion system inner membrane P protein
181 201 PRINTS PR01302 Type III secretion system inner membrane P protein family signature
181 201 InterPro IPR005838 Type III secretion system inner membrane P protein
62 84 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 252 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
229 241 ProSitePatterns PS01061 Flagella transport protein fliP family signature 2.
229 241 InterPro IPR005838 Type III secretion system inner membrane P protein
19 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
194 220 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
190 212 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
56 248 Pfam PF00813 FliP family
56 248 InterPro IPR005838 Type III secretion system inner membrane P protein
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
10 253 PANTHER PTHR30587 FLAGELLAR BIOSYNTHETIC PROTEIN FLIP
10 253 InterPro IPR005838 Type III secretion system inner membrane P protein
115 193 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1446
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.924
4 0.758
5 0.438
7 0.344

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3PH
7AH9
P40700 705.0 Da LogP 12.07 TPSA 119.4 2 viol. ✓ Clean CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O)OC(=O…
LDA
7AH9
P40700 229.4 Da LogP 4.48 TPSA 23.1 ✓ Ro5 ✓ Clean CCCCCCCCCCCC[N+](C)(C)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.