Protein profile

PA1449

flagellar biosynthesis protein FlhB

Genome: NC_002516.2

Gene: PA1449 flhB Structure source: AlphaFold UniProt Q9I3Q2
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Amino acids 378
Annotations 5
Features 38
PDB binders 0
Druggability 0.929

Overview

Basic information about this protein and its source genome.

Accession
PA1449
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1449 flhB
Status
annotated
Amino acids
378
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0009306 The controlled release of proteins from a cell. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.929
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records
Show feature table
Start End DB Term Name
97 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 354 NCBIfam TIGR00328 flagellar biosynthesis protein FlhB
8 354 InterPro IPR006136 Flagellar biosynthetic protein FlhB
123 142 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
245 352 SUPERFAMILY SSF160544 EscU C-terminal domain-like
245 352 InterPro IPR029025 Type III secretion system substrate exporter, C-terminal
73 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
271 356 FunFam G3DSA:3.40.1690.10:FF:000001 Flagellar biosynthetic protein FlhB
8 348 Pfam PF01312 FlhB HrpN YscU SpaS Family
8 348 InterPro IPR006135 Type III secretion system substrate exporter
145 167 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
193 215 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 355 PANTHER PTHR30531 FLAGELLAR BIOSYNTHETIC PROTEIN FLHB
4 355 InterPro IPR006135 Type III secretion system substrate exporter
195 215 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
143 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
37 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
166 194 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
271 360 Gene3D G3DSA:3.40.1690.10 secretion proteins EscU
271 360 InterPro IPR029025 Type III secretion system substrate exporter, C-terminal
37 59 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
209 227 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
209 227 InterPro IPR006135 Type III secretion system substrate exporter
229 246 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
229 246 InterPro IPR006135 Type III secretion system substrate exporter
273 288 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
273 288 InterPro IPR006135 Type III secretion system substrate exporter
303 324 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
303 324 InterPro IPR006135 Type III secretion system substrate exporter
11 33 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
11 33 InterPro IPR006135 Type III secretion system substrate exporter
1 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
62 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
95 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
220 270 Gene3D G3DSA:6.10.250.2080 -
216 378 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 27 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1449
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.929
10 0.436
6 0.248
9 0.228