Protein profile

PA1450

hypothetical protein

Genome: NC_002516.2

Gene: PA1450 Structure source: AlphaFold UniProt Q9I3Q1
Export view
Amino acids 419
Annotations 0
Features 32
PDB binders 0
Druggability 0.976

Overview

Basic information about this protein and its source genome.

Accession
PA1450
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1450
Status
annotated
Amino acids
419
Structure source
AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.976
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
237 241 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
219 238 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
314 333 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
13 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
31 194 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 30 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
28 419 PANTHER PTHR30373 UNCHARACTERIZED
376 419 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
295 313 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
264 269 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
219 236 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
352 356 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
242 264 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
195 212 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
383 419 MobiDBLite mobidb-lite consensus disorder prediction
213 218 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
290 294 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
357 375 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
45 168 Pfam PF04536 TPM domain
45 168 InterPro IPR007621 TPM domain
269 291 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
334 351 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
295 314 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
37 179 Gene3D G3DSA:3.10.310.50 -
270 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 30 SignalP_EUK SignalP-noTM SignalP-noTM
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
242 263 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
195 212 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1450
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.976
2 0.796
3 0.508
10 0.266